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23 Cards in this Set
- Front
- Back
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MOA of nystatin
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interacts with ergosterol in fungal cell mem to form pores lined by hydrophilic groups causing leakage of intracell constituents
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MOA of the azoles
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demethylates lanosterol to inhibit the synthesis of ergosterol
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Only azole that penetrates into CNS
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fluconazole
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azoles with activity against Aspirgillus
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itraconazole and voriconazole
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infusion related events of amphotericin B; what drugs to give?
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chills and fever (shake and bake), muscle spasms, nausea, HA and hypotension; antipyretics, antihistamines, glucocorticoids
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dose limiting toxicity of amphotericin B
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renal tubular acidosis
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can opportunistic candidal infections be prevented by prophylaxis?
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no, but other opportunistic infections can
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should a healthy person be treated for pulmonary sx of coccidioidomycosis?
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no, it is self limiting
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what does erythema nodosum in coccidioidomycosis signify?
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delayed hypersensitivity reaction and good prognostic sign
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DOC for persistent or disseminated coccidioidomycosis?
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fluconazole or itraconazole (increased risk of dissemination in African Am or preg women)
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oral drug least likely to be effective against esophageal candidiasis: amphotericin B, clotrimazole, fluconazole, griseofulvin, ketoconazole
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griseofulvin, it's not active against candidia, only against dermatophytes
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MOA of flucytosine
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converted via fungal cytosine deaminase to fluorouracil which inhibits thymidylate synthase to prevent production of purines
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cardiotoxicity may occur with use of this drug while also taking astemizole or terfenadine (antihistamines); why?
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ketoconazole; it inhibits their metabolism via P450
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DOC for oral use in vaginal candidiasis
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fluconazole
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the liposomal formulation of amphotericin B decreases what complications?
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nephrotoxicity
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what inhibitor of fungal cell wall component synthesis can be used for disseminated and mucocut candida?
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caspofungin; inhibits the synthesis of beta(1-2)glycan
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Antifungal agent used for inhibition of all gonadal and adrenal steroids
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Ketoconazole
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DOC for aspergillus, blastomyces, candida, cryptococcus, histoplasma and mucor
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amphotericin B
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DOC for cryptococcus, chromoblastomycosis
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flucytosine
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SE of voriconazole
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transient visual disturbances
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MOA of griseofulvin
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interferes with microtubule function in dermatophytes
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what drug should not be given to a pt with porphyria?
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griseofulvin
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MOA of terbinafine
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inhibits squalene epoxide causing squalene to accumulate and interfere with ergosterol synthesis
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