Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
26 Cards in this Set
- Front
- Back
|
Example of a low molecular weight heparin (LMWH))
|
Enoxaparin (Lovenox) works on factor 10a
|
|
|
what is argatroban
|
a direct thrombin inhibitor;
used as an alternative to heparin |
|
|
which factors does warfarin (Coumadin) work on?
|
2,7,9,10
also on thrombomodulin which is proteins S and C inteferes with vit K synthesis |
|
|
direct thrombin inhibitors
|
Hirudin
Lepirudin Evaliridin Argatraban |
|
|
how does heparin work?
|
activates antithrombin which inhibits factors IIa (thrombin), Xa, others
|
|
|
what is factor IIa
|
Thrombin
|
|
|
when you you use thrombolytics
|
MI; they break up fibrin clots
|
|
|
how does fondaparinux (Arixtra)
|
directly inhibits factor Xa and XI
|
|
|
What does Heparin do?
|
activates antithrombin which inhibits factors IIa (thrombin), Xa, XIa and Xa
|
|
|
when should you use Argatroban?
|
with a pt with heparin induced thrombocytopenia
|
|
|
indications of heparin
|
MI, thromboembolism, ACS, prevention of thromboembolism
|
|
|
heparin treatment dose
|
infusion
|
|
|
haparin propholaxis dose
|
5000 subq every 8-12 hrs to prevent a clot
|
|
|
side effects of heparin
|
TCP-thrombocytopenia
HIT-heparin induced thcytpnia |
|
|
Lovenox indications
|
acute MI, ACS, Thromboembolism
|
|
|
Lovenox TX dosing and side effects
|
1 mg/kg SC q12; if CrCl <30 then q24 hr
side effects: bleeding |
|
|
lovenox prophylaxis dose
|
30 mg SC q12
side effects: TCP, HIT |
|
|
Arixtra indications
|
Tx of thromboembolisms
|
|
|
Arixtra Tx dosing
|
5-10 mg (based on wt)SC once daily
side effects: Bleeding |
|
|
Arixtra prophylaxis dose
|
2.5 mg SC once daily
side effects: Thrmbcytpenia |
|
|
Argobatran indications
|
heparin induced Thrmbcytpenia
ischemic stroke MI |
|
|
Argobatran dosing
|
depends on indication; drip formulation; hepatically cleared, don't use with liver failure
side effects: Bleeding |
|
|
coumadin indications
|
Thrmboembolism (Afib, post MI, Venous TE, heart valves)
|
|
|
Specific Xa anticoagulant
|
Arixtra
|
|
|
how long does Warfarin take to have its effects
|
3-5 days, it is not an acute drug
|
|
|
purple toe syndrome
|
may be caused by too high an initial warfarin dose
|
