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10 Cards in this Set
- Front
- Back
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Fluoroquinolones
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MOA is inhibiting DNA gyrase in bacterial cells. Gyrase is equivalent to topoisomerase II. They inhibit the resealing of the cut that gyrase makes. Very broad spectrum of treatment and maybe overused.
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DNA gyrase
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Two dimers form a tetramer. Mutations in this give resistance to fluroquinolones.
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Concentration dependent killing is used in which two antibiotics.
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Aminoglycosides and Fluroguinolones.
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What is the suffix for many fluroquinolones.
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-floxacin
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What is the fluroquinolone you would want to use for pseudomonas infections.
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Ciprofloxacin
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What fluroquinolone would you give for strep.
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Levofloxacin or moxifloxacine. They are referred to as respiratory fluros. DON'T GIVE CIPRO
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What do you want to avoid taking when on fluros.
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Heavy metals in antacids block absorbtion.
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Adverse effects of fluros.
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Normal stuff like headaches. Black box warning for tendon rupture. Potential cartilage damage in children. Hypoglycemia with glyburide.
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What do we need to be aware of someone on cipro.
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Inhibits metabolism of theophylline and warfarin.
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Rifamycins (Rifampin)
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Inhibits bacterial DNA-dependent RNA polymerase. Rapid resistance develops. Usually preserved for N. meningitidis. Combo with vanco for MRSA or macrolide for legionella.
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