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38 Cards in this Set
- Front
- Back
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methotrexate
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blocks DHFR
antidote is leucovorin nephrotoxic, myelosuppression, pulmonary tox, hepato tox, GIT mucositis |
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5-FU
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is a pyrimidien analogue, inhibits thmidylate synthase
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capecitabine
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metabolized into 5-FU
new drug for pancreatic cancer |
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cytarabine
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incorporated into DNA and disruptes
used for AML neurotox |
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mercaptopurine
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purine analogue, inhibiting PRPP synthetase
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azathioprine
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purine analogue, inhibiting PRPP synthetase
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vincristine
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CSS-M-binds tubulin. Neurotox
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vinblastine
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CSS-M, binds tubulin, myelotoxic
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etoposide
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CSS-S/G2- stabalizes Top II so dsDNA breaks.
AE is leukopenia |
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topotecan
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CSS-S/G2 stabalizes Top I so dsDNA breaks
AE are neutropenia, thrombocytopenia, crosses BBB |
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paclitaxel
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CSS-M- binds tubulin, causes MIT disassembly and dysfunctional spindles
AE meylosuppression |
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cyclphosphamide
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converted into nitrogen mustard, an alkylating agent.
AE is hemorrhagic cystitis from acrolein end product, amenorrhea and azoospermia, renal, bladder, and cardio tox, as well as cause SIADH antidote is Mesna for general or demeclocyline for SIADH |
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carmustine
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CCNS alkylating agent
used fro brain tumors crossing BBB myelosuppression |
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cisplatin
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platinum alkylating, cross links DNA
used for testicular cancer neph and neuro tox antidote is amifostine |
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temozolomide
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non-corsslinking alkylating agent through methylation
used for maligant gliomas |
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fulvestrant
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hormonal, estrogen receptor antagonist
used in tamoxifen resist breast CA |
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tamoxifen
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hormonal, blocks estrogen receptor binding
used for breast cancer |
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anastrozole
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hormonal, aromatase blocker
used in breast cancer |
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flutamide
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hormonal, blocks translocation of steroid receptors into nucleus
used in prostate cancer |
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finasteride
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hormonal, blocks 5-alpha reductase
used in prostate cancer |
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leuprolide
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hormonal, GnRH agaonist inhibiting LH and FSH release
used in prostate cancer must be admin at constant dose |
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daunorubicin
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CCS-S and CCNS. Blocks top II and creates free radicals.
AML AE cardiomyopathy and meylosuppression antidote dimethyl sulphoxide and dexrazoxane |
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doxorubicin
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CCS-S and CCNS. Blocks top II and creates free radicals.
AE cardiomyopathy and meylosuppression antidote dimethyl sulphoxide and dexrazoxane |
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dactinomycin
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CSS-S and CCNS. Binds DNA helix and causes single strand breaks in transcription.
Wilm's tumor use myelosuppression |
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bleomycin
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CSS-G2and CCNS. Free radical formation fragments DNA
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rituximab
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monoclonal Ab to CD20
used in NHL |
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trazuzumab
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monoclonal Ab, IgG1 anti-HER2
used in breast CA AE cardiac dysfunction |
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asparaginase
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antimetabolite that hydrolyzes L asparagine
used for AML |
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imatinib
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monoclonal AB, anti-bcr-abl tyrosine kinase
used for CML |
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hydroxyurea
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antimetabolite that inhibits riobnucleotide reductase
used in CML |
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pentostatin
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blocks adensoine deaminase
used for Hairy cell leukemia |
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Breast Cancer
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CMF
Cyclophosphamide Methotrexate 5-FU |
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Colorectal cancer
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FOLFOX
Foluvic acid 5-FU oxaliplatin |
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Ovarian cancer
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CP
Cisplatin and Paclitaxel |
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Testicular cancer
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PVB
cisPlatin Vinblastine Bleomycin |
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Non-Hodgkins
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CHOP + rituximab
Cyclophosphamide doxorubicin (Hydroxydaunarubicin) vincristine (Oncovorin) Prednisone |
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Hodgkins
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MOPP
mechlorethamine vincristine (Oncovorin) Predisone Procarbazine |
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Hodgkins
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ABVD
doxorubicin (Adriamycin) Bleomycin Vinblastine Dacarbazine |
