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42 Cards in this Set
- Front
- Back
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PNS toxicity
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vincristine
paclitaxel |
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heart toxicity
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doxorubicin
|
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lung toxicity
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bleomycin
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kidney toxicity
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cisplatin
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urinary bladder toxicity
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cyclophosphamine
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TX BM suppression caused by methotrexate
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leucovorin
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leucovorin MOA
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treats BM suppression by methotrexate
only normal cells can take up used to make THF |
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Hydroxyurea MOA
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-S phase
-inhibits ribonucleotide reductase -turns on HbF gene |
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Hydroxyurea Tx
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sickle cell
melanoma CML |
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5'-FU MOA
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S-phase
pyrimidine analog inhibits Thymidylate Synthase |
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5'-FU Tx
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actinic keratosis
colon cancer solid tumors synergistic w/ methotrexate |
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synergistic w/ methotrexate
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5'-FU
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folic acid analog
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MTX
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Methotrexate MOA
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folic acid analog
inhibit DHF reductase |
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inhibit DHF reductase
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Methotrexate
|
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S-phase drugs
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Hydroxyurea
5'-FU Methotrexate 6-MP Cytrarabine Azacitdine |
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G2-Phase Drugs
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Bleomycin
Etopiside |
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Bleomycin MOA
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breaks DNA, forms free radicals
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M-phase drugs
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vinka alkaloids
(vincristine and vinblastine) taxols (docetaxel and paclitaxel) colchine |
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derm toxicity
|
docetaxel
(M-phase) |
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cardio toxicity
|
doxorubicin
CCNS |
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liver toxicity
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asperginase
CCNS |
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nephrotoxic
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cisplatin
CCNS carboplatin CCNS |
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acoustin toxic
|
cisplatin
carboplatin CCNS |
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urinary bladder toxic
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cyclophosphamide
CCNS |
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occular toxic
|
docetaxel (M-phase)
5'FU (S-phase) |
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Cytarabine
|
s-phase
|
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Azacitidine
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S-phase
|
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S-phase druge
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hydroxyurea
5'FU Methotrexate 6-'mercaptopurine azacitidine cytarabine |
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G2-phase
|
bleomycine
etopside |
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M-phase
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vinc-alkaloids
taxols colchicine |
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colchicine
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M-phase
|
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Etoposide
|
G2-phase
|
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nephrotoxic
|
cisplatin
carboplatin |
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derm toxic
|
docetaxel (M-phase)
also occular toxicity |
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Myelosupression
|
5'-FU
Methotrexate 6-mercaptopurine |
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hemorragic cystitis
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cyclophosphamide
CCNS |
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cyclophosphamide
|
hemorragic cystitis
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CNS toxicity
|
cytarabine (S-phase)
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imantinib MOA
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blocks TK in cancer cells from binding ATP
prevents WBC proliferation |
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MOA bortexomib
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(-) 26s proteosome
prevent degredation IK-B--> NK-FB never "on" |
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MOA Rituximab
|
monoclonal Ab
binds CD20 on malignant BC complement destruction |
