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9 Cards in this Set
- Front
- Back
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COX-1
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constitutional "housekeeping"
can be induced 2-4x vascular endothelium, smo. muscle, stomach, platelets |
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COX-2
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inducible in inflammatory cells
constitutive in kidney 20-40x inducible |
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Asprin target
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COX-1 and COX-2
irreversible acetylation of active sites |
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Salicylate target
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COX-1 and COX-2
reversible inhibition |
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COX-1 inhibitor
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Indothacin
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COX-2 inhibitor
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Celecoxib
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Glucocorticoid MOA
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induce LIPOCORTIN --> decrease PLA2--> decrease both PG and LTs
supress synthesis of COX-2 |
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glucocorticoids
adverse effects |
PREDNISONE
mneumonic |
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what to give a previous aspirin hypersensitivity pt?
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acetominophen
celecoxib (will react w/ all other NSAIDs) |
