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56 Cards in this Set
- Front
- Back
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Epinephrine
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1. a1, a2, b1, b2
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Norepinephrine
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2. a1, a2, b1 (no b2 activity)
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GABA
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3. Causes an inhibitory cell hyperpolarization
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Muscarinic-r
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4. Uses DAG & IP3 as 2nd messengers
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5. Parasympathetic control
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Bethanechol
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6. Cholinergic. GI & Bladder motility. Txt atonic bladder post-op
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Pilocarpine
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7. Cholinergic. Pupillary constriciton= miosis. Ciliary constriction= accomodation.
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8. Txt acute glaucoma
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Isoflurophate
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9. Organophosphate. Irreversible acetylcholinesterase (-)r
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Pralidoxime
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10. “2PAM”. Reverses organophosphate binding to acetylcholinesterase
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Neostigmine
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11. Reversible acetylcholinesterase (-)r
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12. Txt Myasthenia Gravis
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Myasthenia Gravis
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13. Anitbodies to Ach-r. ’g muscular weakness due to Ach’s weak postsynaptic effect @ NMJ. Inactivates-r
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Tubocurium
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14. Nondepol. Competitive cholinergic N-r (-)r.
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15. Prevents Ach binding but does not activate NMJ
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16. Histamine release= ¯ BP & bronchospasm
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Trimethaphan
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17. Nonselectively binds N-r of the PS- and SNS
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Pancurium
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18. More potent than tubocurium w/o histamine release
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Succinylcholine
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19. Depol. Non competitive (-)r of muscle aciton
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20. Opens Na Ch.= fasciculations. Closes Na Ch.= paralysis. Continuous infusion.
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a1 & Eye
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21. Mydriasis due to norepinephrine. Prazosin (-).
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M-r & Eye
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22. Miosis due to Ach. Atropine (-).
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Sympathetic
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23. Post ganglionic symapthetic fibers releases norepinephrine
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Parasym.
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24. Post ganglionic parasympathetic fibers release Ach
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M3-r & Eye
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25. Contracts sphincter = miosis. Contracts ciliary = accomodation.
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M2-r & Heart
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26. Negative chronotropy: ¯ HR = vagal arrest
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27. Negative inotropy: ¯ contractility
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M3-r & Lung
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28. Bronchospasm secretions
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M3-r & GI
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29. motility (cramps & diarrhea). Involuntary defecation
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Tacrine
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30. Acetylcholine esterase (-)r. Txt Alzheimer’s
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Atropine
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31. DOC w/ vagal arrest
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Glycoperrolate
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32. M-r(-). Antispasmodic. Txt peptic ulcers.
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Pirenzepine
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33. M-r(-). Antispasmodic. Txt peptic ulcers.
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Doxacurium
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34. Most potent competitive non-depol NMJ (-)r. No cardiovascular side effects. No Histamine release.
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b bungarotoxin
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35. Prevent the releasal of Ach from vesicles @ the pre synaptic nerve ending
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a bungarotoxin
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36. Irreversible N-r (-)r = ¯ action potentials
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a1 & Eye
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37. Contracts radial muscle = mydriasis (pupil dilation)
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a1 & Arterioles
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38. Constiction: TPR = Diastolic pressure = Afterload
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a1 & Venules
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39. Constriction: Venous return = Preload
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a1 & Sex Function
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40. Ejaculation
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Diastolic
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41. a1 = TPR
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¯ Diastolic
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42. b2; Direct acting vasodilators; (+)Cholinergics
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b1 & Heart
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43. (+)chronotropism = HR.
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44. (+)inotropism = contractility; SV; CO; O2 consumption.
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45. conduction velocity
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Phenylephrine
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46. a1 (+) Nasal decongestant.
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b2(+) Asma Drugs
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47. Metaproterenol; Albuterol; Terbutaline; Ritodrine; Salmeterol
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Ritodrine/Turbutaline
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48. Relaxes myometrium used in pre-mature labor pains
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Phentolamine
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49. Epi reversal. Blocks a, vasodilation occurs. Pt goes from HyperTN to HypoTN.
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50. Txt pheochromocytoma = ¯BP
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Terazosin
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51. Txt BPH
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Yohimbine
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52. sympathetic outflow = a2 (-). Txt impotence.
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Cardioselective NMJ
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53. Pancuronium = HR due to atropine-like anti muscarinic vagolytic effect & Gallamine (-)r
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Ecothiophate
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54. Irreversible cholinesterase (-)r.
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Pyridostigmine
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55. Cholinomimetic that s M & N-r effects. (-) acetylcholinesterase & plasma cholinesterase
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56. DOC for the oral Txt of MG
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