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56 Cards in this Set

  • Front
  • Back
Epinephrine
1. a1, a2, b1, b2
Norepinephrine
2. a1, a2, b1 (no b2 activity)
GABA
3. Causes an inhibitory cell hyperpolarization
Muscarinic-r
4. Uses DAG & IP3 as 2nd messengers
5. Parasympathetic control
Bethanechol
6. Cholinergic. ­ GI & Bladder motility. Txt atonic bladder post-op
Pilocarpine
7. Cholinergic. Pupillary constriciton= miosis. Ciliary constriction= accomodation.
8. Txt acute glaucoma
Isoflurophate
9. Organophosphate. Irreversible acetylcholinesterase (-)r
Pralidoxime
10. “2PAM”. Reverses organophosphate binding to acetylcholinesterase
Neostigmine
11. Reversible acetylcholinesterase (-)r
12. Txt Myasthenia Gravis
Myasthenia Gravis
13. Anitbodies to Ach-r. ­’g muscular weakness due to Ach’s weak postsynaptic effect @ NMJ. Inactivates-r
Tubocurium
14. Nondepol. Competitive cholinergic N-r (-)r.
15. Prevents Ach binding but does not activate NMJ
16. ­ Histamine release= ¯ BP & ­ bronchospasm
Trimethaphan
17. Nonselectively binds N-r of the PS- and SNS
Pancurium
18. More potent than tubocurium w/o histamine release
Succinylcholine
19. Depol. Non competitive (-)r of muscle aciton
20. Opens Na Ch.= fasciculations. Closes Na Ch.= paralysis. Continuous infusion.
a1 & Eye
21. Mydriasis due to norepinephrine. Prazosin (-).
M-r & Eye
22. Miosis due to Ach. Atropine (-).
Sympathetic
23. Post ganglionic symapthetic fibers releases norepinephrine
Parasym.
24. Post ganglionic parasympathetic fibers release Ach
M3-r & Eye
25. Contracts sphincter = miosis. Contracts ciliary = accomodation.
M2-r & Heart
26. Negative chronotropy: ¯ HR = vagal arrest
27. Negative inotropy: ¯ contractility
M3-r & Lung
28. Bronchospasm ­secretions
M3-r & GI
29. ­ motility (cramps & diarrhea). Involuntary defecation
Tacrine
30. Acetylcholine esterase (-)r. Txt Alzheimer’s
Atropine
31. DOC w/ vagal arrest
Glycoperrolate
32. M-r(-). Antispasmodic. Txt peptic ulcers.
Pirenzepine
33. M-r(-). Antispasmodic. Txt peptic ulcers.
Doxacurium
34. Most potent competitive non-depol NMJ (-)r. No cardiovascular side effects. No Histamine release.
b bungarotoxin
35. Prevent the releasal of Ach from vesicles @ the pre synaptic nerve ending
a bungarotoxin
36. Irreversible N-r (-)r = ¯ action potentials
a1 & Eye
37. Contracts radial muscle = mydriasis (pupil dilation)
a1 & Arterioles
38. Constiction: ­TPR = ­ Diastolic pressure = ­ Afterload
a1 & Venules
39. Constriction: ­ Venous return = ­ Preload
a1 & Sex Function
40. Ejaculation
­ Diastolic
41. ­ a1 = ­TPR
¯ Diastolic
42. ­ b2; Direct acting vasodilators; (+)Cholinergics
b1 & Heart
43. (+)chronotropism = ­HR.
44. (+)inotropism = ­ contractility; ­SV; ­CO; ­O2 consumption.
45. ­ conduction velocity
Phenylephrine
46. a1 (+) Nasal decongestant.
b2(+) Asma Drugs
47. Metaproterenol; Albuterol; Terbutaline; Ritodrine; Salmeterol
Ritodrine/Turbutaline
48. Relaxes myometrium used in pre-mature labor pains
Phentolamine
49. Epi reversal. Blocks a, vasodilation occurs. Pt goes from HyperTN to HypoTN.
50. Txt pheochromocytoma = ¯BP
Terazosin
51. Txt BPH
Yohimbine
52. ­ sympathetic outflow = a2 (-). Txt impotence.
Cardioselective NMJ
53. Pancuronium = ­HR due to atropine-like anti muscarinic vagolytic effect & Gallamine (-)r
Ecothiophate
54. Irreversible cholinesterase (-)r.
Pyridostigmine
55. Cholinomimetic that ­s M & N-r effects. (-) acetylcholinesterase & plasma cholinesterase
56. DOC for the oral Txt of MG