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31 Cards in this Set
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- Back
- 3rd side (hint)
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* alpha-methyl-paratyrosine (metyrosine)
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TH inhibitor
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Inhibitor of Tyrosine hydroxylase prevents tyrosine -> L-Dopa. Used in pheochromocytoma. (Crystallizes in urine-hematuria)
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* reserpine
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blocks catecholamine packaging
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reduces hypertension (severe depression)
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* guanethidine
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blocks catecholamine packaging/release
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reduces hypertension. Charged. No CNS. Long 1/2; (orthostatic hypotension) (retrograde ejaculation). Requires uptake 1
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* guanadrel
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blocks catecholamine packaging/release
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Like guanethidine but shorter 1/2 life
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* tyramine
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blocks catecholamine uptake 1/+release
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"Induce catecholamine release when taken up. Peripheral. Found in pickeled herring, wine"
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* cocaine
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blocks catecholamine uptake 1
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inhibitor of catecholamine re-uptake. Especially norepinephrine -> stimulatory
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* imipramine
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Block catecholamineuptake 1
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pargyline
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MAO inhibitor
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"treat depression. (Tyramine diets(wine, pickeled herring) ->induce catecholamine release=>hypertensive crisis)"
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* deprenyl
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MAO-B inhibitor
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prevents metabolism of Dopamine. Treat Parkinson's
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SSRI anti-depressants
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block serotonin uptake
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keeps more serotonin in synapse - anti-depressant
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* MPTP
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Toxin met. By MAO to MPP+
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Metabolised by MAO to MPP+. Causes Parkinson's
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* carbidopa
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Blocks AAAD
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Prevents conversion of L-Dopa to Dopamine in periphery. Treat Parkinson's (more L-dopa gets to brain)
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* L-dopa
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Converts to dopamine. Treat Parkinson's
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Converts to dopamine. Treat Parkinson's
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* nitecapone
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COMT inhibitor
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Prevents metabolism of Dopamine to 3-methoxytyramine.cytoplasmic. Treat Parkinson's because less L-Dopa->dopamine
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* norepinephrine
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"a, B1 agonist"
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* epinephrine
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"a,b agonist"
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* methoxamine
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a1 agonist
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increase BP by causing vasoconstriction
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* phenylephrine
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a1 agonist
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increase BP by causing vasoconstriction
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* clonidine
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a2 agonist
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lower blood pressure
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* alpha-methylnorepinephrine
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a2 agonist
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lower blood pressure
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* isoproterenol
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B agonist
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increase HR/contractility (via B1) and dilate bronchioles (via B2)
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* dobutamine
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B1 agonist
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increase HR/contractility (via B1). Treat CHF
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* albuterol
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B2 agonist
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dilate bronchioles. Treat asthma
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* terbutaline
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B2 agonist
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dilate bronchioles. Treat asthma
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* phenoxybenzamine
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"a antagonist, irreversible"
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lower blood pressure. Treat patients with pheochromocytoma prior to surgery
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* phentolamine
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"a antagonist, reversible"
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Used in OR to counteract catecholamine release during surgery
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* prazosin
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a1 antagonist
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antihypertensive (decrease vascular tone)
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* yohimbine
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a2 antagonist
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ED drug
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* propranolol
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"B1, B2 antagonist"
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"Treats cardiac arrhythmias, angina pectoris, hypertension, but blocking B2=broncho constriction (Not for asthmatics)"
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* atenolol
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B1 antagonist
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Treat hypertension
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* amphetamines
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block uptake/+release/-MAO
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"inhibitor of uptake 1, indrect releasing of vesicular catecholamine, MAO inhitor"
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