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30 Cards in this Set
- Front
- Back
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Over activation of nicotinic receptors can lead to a
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Depolarizing block (flaccid paralysis)
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Choice ACh inhibitor to increase GI and urinary activity
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Neostigmine
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Difference b/w neostigmine and physostigmine
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Neostigmine doesn't enter the CNS
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Pyridostigmine benefits compared to other ones
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Longer duration of action
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Drugs more selective for CNS AChE and used as treatment for Alzheimer's disease
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Tacrine, Donepezil, Galantamine, Rivastigmine
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Irreversible AChEs Uses
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1) Treatment of glaucoma
2) Increase GI activity/tone 3) Treatment of myasthemia gravis 4) Insecticide 5) Nerve gas |
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Soman, Sarin, and Tabun are
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Nerve gases
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Malathion, Parathion are
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Insecticides
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Atropine is non-selective for M subtypes
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Notes
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How does atropine affect glaucoma patients?
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BAD- increases intraocular pressure
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Atropine side effects
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Dry as a bone, blind as a bat, red as a beet, mad as a hatter
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Category for physostigmine
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Reversible Anti-cholinesterase
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Category for neostigmine
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Reversible anti-cholinesterase
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Category for Pyridostigmine
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Reversible anti-cholinesterase
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Category of Ambenonium
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Reversible Anti-cholinesterase
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What are the irreversible anticholinesterases?
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Isoflurophate, Soman, Echothiphate, Parathion
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Antidotes to Anti-AChesterases
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1) Atropine
2) Ventilate 3) Prevent absorption 4) Competition- introduce reversible to compete with irreversible |
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Category of Scopolamine
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Anti-muscarinic
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Category of ganglionic blockers
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Anti-nicotinic agents
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Category of Tropicamide
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Muscarinic Antagonist
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Category of Homatropine
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Muscarinic Antagonist
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Category of Ipratropium
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Muscarinic Antagonist
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Tx Ipratropium
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Asthma, COPD
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Category of Glycopyrrolate
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Muscarinic antagonist
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Category of Oxybutynin
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Muscarinic antagonist
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Category of Tolterodine
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Muscarinic antagonist
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Category of Physostigmine
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Reversible Anti-AChE
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Choice drug for glaucoma
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Pilocarpine
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Mecamylamine
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Ganglionic Blocker
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Ganglionic blockers used for
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Controlled hypotension
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