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23 Cards in this Set

  • Front
  • Back
- Muscarinic Antagonist
- Tertiary amine that can penetrate CNS
- blocks iris contraction -> mydriasis
- blocks ciliary contraction -> cycloplegia
- blocks GI secretions and motility
- decreases sweating
- makes you blush
- causes mild tachycardia
– no BP effects - BVs not para innervated
- causes bronchial relaxation
- Muscarinic Antagonist
- like atropine but more CNS action, esp drowsiness and amnesia
- this suggests central ACh playa a role in memory
- used as patch for motion sickness
- Muscarinic Antagonist
- Quaternary amine
- inhalate in reversible airway disease if bronchial constriction due to increased para stimulation
Muscarinic Antagonist uses
- before surgery - atropine and scopolamine reduce salivary and respiratory secretions and induce amnesia
- motion sickness
- parkinsons
- intestinal spasms
- for eye exams (atropine)
Nondepolarizing ganglionic blockers
- compete w/ ACh at nicotinic R to prevent depol of the post membrane
- like curare at NMJ
- Nondepolarizing ganglionic blocker
- a charged sulfonium salt (IV) - diffuses poorly so rapidly metabolized
- response depends on what division dominates
- rarely used due to side effects – maybe for short term control of BP in hypertensive emergencies
depolarizing ganglionic blocker
- initially activates receptor -> depol
– b/c it stays in a depol state, it no longer responds to ACh
- resembles succinylcholine at the NMJ
- no clinical use
- depolarizing ganglionic blocker
- PNS, initial stimulation, then more persistent depression at all autonomic ganglia and adrenal medulla -> hypertension & arrhythmias
- NMJ, brief stimulatory phase, then persistent depol blockade -> SkM paralysis
- CNS - stimulates resp -> tremor and vomiting -> convulsion and death from resp depression
Competitive or Nondepolarizing Neuromuscular Blocking Agents
block ACh receptors at the motor endplate, depressing the amplitude and duration of EPP below the threshold
- Competitive neuromuscular ACh Blocking Drug
- paralyzes SkM starting w/ the eys and going out
- high dose can disrupt auntonomic ganglia and cause hypotension
- can cause histamine release
- actions enhanced by general anesthetics and Abs
- Competitive neuromuscular ACh Blocking Drug
- shorter duration (35-45 min) than DT
- action ends b/c of metab
- use in anephric patients
- Has some histamine release
- Competitive neuromuscular ACh Blocking Drug
- Has shorter duration (25-40 min) than DT
- terminated by excretion in bile and kidney
- no histamine release or ganglionic blockade
- Competitive neuromuscular ACh Blocking Drug
- has less histamine release and is very short acting (~ 16 min.) comared to DT
- Noncompetitive (depol)neuromuscular ACh Blocker
- persistent depol of the motor endplate (Phase I block)
- IV -> muscle twitches for 1 min, SkM paralysis for 5
- repeat blockade and it may become a nondepolarizing blockade (Phase II block) where its desensitized to ACh - so try not to do this
- used for Adjuvant in surgical anesthesia, Prevent trauma during electroshock therapy, Aid in setting fractures or intubating
scopolamine trade name
(Isopto Hyoscine Scopace)
ipratropium trade name
nicotine trade name
(Nicorette; Habitrol; Prostep)
trimethaphan trade name
D-tubocurarine trade name
atracurium trade name
vecuronium trade name
mivacurium trade name
succinylcholine trade name
(Anectine; Quelicin)