Pharm

Front 1

hydroxyurea

Back 1

inhibits ribonuclotide reductase, treatment of sickel cell, Increases HbF, so inhibits polymerization of HbS.

Front 2

Mitotane

Back 2

indicated for palliation of inoperable adrenal corticak carcinoma.

Front 3

Etoposide
Teniposide

Back 3

inhibits topoisomerase II, DNA damage by strand breakage, block cell in G2 phase, NO penetration in BBB.

Front 4

Camptothecins

Back 4

Inhibit topoisomerase I, DNA damage, cell arrest at G2 phase ...cell death

Front 5

Irinotecan

Back 5

CAmptothecins:
diarrhea, hypovolemia, mylosuppresion.

Front 6

Topotecan:

Back 6

Camptothecins:
Neutrophenia, thrombocytopenia, anemia, nausea, vommiting, alopecia.

Front 7

Diethylstilbestrol,
ethinylestradiol

Back 7

They are estrogens:

prostate cancer, suppresses LH secretion via negative feed back, decreases testosteroen producgtion.
AE: MI, Stroke, thromboemboli

Front 8

Tamoxofen,
Toremifene

Back 8

Are estrogem receptor modulators: Estrogen inhibitors;

receptor positive breast cancer and endometrium.
AE: Hot flashes and fluid retension.

Front 9

Fulvestrant:

Back 9

Estrogen receptor Downregulators:
decreases # of ER molecules in cells and binds to estrogen receptors 100X than Tamoxifen ...degradation.

Front 10

Anastrozole,
Letrozoles

Back 10

reversible, Aromatase inhibitors

Front 11

Exemestane,
Formestane

Back 11

Irreversible: Aromatase inhibitors.

Front 12

collections of symptoms: Tinnitus, blurred vision, GI upset, and delirium.

Back 12

Cinchonism: side effect of quinidine toxicity. EKG changes, prolongation of QT and QRS intervals may also occur.

Front 13

cuteneous flusshing and pruritus

Back 13

Niacin

Front 14

Turner patients:

Back 14

estrogen and progestins: since unopposed estrogen can cause atypical adenomatous hyperplasia of endometrium.

Front 15

meperidine

Back 15

most likely to be abused due to ots fulll effect on MU receptors causing euphoria.

Front 16

Finasteride

Back 16

an inhibitor of 5 alpha reductase, prevents conv of testosterone to DHT thus, helpful in treating bening hyperplasia.

Front 17

cisplatin

Back 17

notable for dose limiting nephrotoxicities and ototoxicity.

Front 18

Allopurinol

Back 18

decreases uric acid production in both serum and urine. it inihibts xanthine oxidase.

Front 19

N acetylcysteine

Back 19

used in the overdose of acetaminophen.

Front 20

heparin toxicity

Back 20

protamine sulfate

Front 21

warfarin toxicity

Back 21

vit K and fresh frozen plasma.

Front 22

dextrometorphane

Back 22

cough, syn morphine derivativecentrally acting to supress coughit doesn't produce sighnificant addiction.

Front 23

misoprostol

Back 23

anti ulcer, but not used in pregnancy (abortificat). it is methyl analog of prostaglandin E1.

Front 24

cell cycle specific for M phase

Back 24

vinca alkaloids.

Front 25

Pk enhancer/booster of other Protease inhibitors

Back 25

ritonavir

Front 26

cannot be boosted by other ritonavir

Back 26

nelfinavir(protease inhibitors)

Front 27

severe fatal hepatitis or intercranial hemmoraGES

Back 27

tipranavir (protease inhibitors)

Front 28

which protease inhibitor had decreased bioavalabilty when taken with food

Back 28

indinavir

Front 29

high fat meals are good for which protease inhibitors)

Back 29

ne;finavir and saquiravir

Front 30

poor intrinsic bioavalibility

Back 30

lopinaivr (protease inhibitors)

Front 31

fat redistribution

Back 31

indinavir (protease inhibitors)

Front 32

prolongs PR interval, slows heart, jaundice, competivite inhibitor of glucuronyl transferease

Back 32

atazanavir (protease inhibitors)

Front 33

oral solution contains ethannol, should not be taken with st john warts

Back 33

lopinaivr

Front 34

inhibits HIV protease resist to other protease inhibitors.

Back 34

tipranavir
darunavir