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15 Cards in this Set
- Front
- Back
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3 zones of adrenal cortex and their products
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Glomerulosa (mineralocorticoids), fasciculata (glucocorticoid=GC), and reticularis (adrenal androgens)
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Pneumonic for 3 zones of adrenal cortex
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GFR
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Used for Addison's disease, Congenital Adrenal Hyperplasia (CAH), inflammation, allergies, and asthma (as a local inhalation)
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Glucocorticoids
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Short acting GC's
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Cortisone and hydrocortisone (equivalent to cortisol)
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Intermediate acting GC's
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Prednisone, methylprednisolone, prednisolone, and triamcinolone
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Long acting GC's
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Betamethasone, dexamethasone, and paramethasone
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Mineralocorticoids
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Fludrocortisone and deoxycorticosterone
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Some side effects of corticosteroids
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Osteopenia, impaired wound healing, inc. risk of infection, inc. appetite, HTN, edema, PUD, euphoria, psychosis, stria, thinning of skin
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Period of time of therapy after which GC therapy will need to be tapered
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5-7 days
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Used for Cushing's syndrome (increased corticosteroid) and sometimes for adrenal function test
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Metyrapone
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Inhibits conversion of cholesterol to pregnenolone therefore inhibiting corticosteroid synthesis
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Aminoglutethimide
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Antifungal agent used for inhibition of all gonadal and adrenal steroids
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Ketoconazole
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Antiprogestin used as potent antagonist of GC receptor
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Mifepristone
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Diuretic used to antagonize aldosterone receptors
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Spironolactone
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Common SE of spironolactone
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Gynecomastia and hyperkalemia
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