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5 Cards in this Set
- Front
- Back
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What are the goals of DMARD therapy?
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reduce symptoms
slow progression of inflammation as evidenced by decreased number of inflamed joints |
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What are the primary inflammatory cytokines in RA?
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IL-1 and TNFa
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Which cells secrete TNF?
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monocytes
macrophages |
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Role of IL-1 in RA
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pro-inflammatory cytokine;
triggers production of other pro-inflammatory cytokines; causes T-cell/neutrophil accumulation in synovium |
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mechanism of methotrexate
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prevents extravasation of inflammatory cells in synovium
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