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28 Cards in this Set
- Front
- Back
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Antiarrhtymic mech of adenosine involves blockade of a. Na channels b. ca channels, c. K channels d. non
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none; involves activation of K channels
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what is contraind in pts with MI?
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propafenone
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class 1 antiarrhythmic drigs a. decrease action potential, cause positive inotropy, used for supraventric arry, rapid myo
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more effective in rapidly beating myocardium
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Class IV antirhym drugs: inc. QT int on EKG; increase refractoriness, act on G protein, used to trt lf thret arr
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none of the above(prolonged plateau phase seen in actn pot of atrial, purkinje, ventricular cells)
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doesnt contrib 2 efficacy of antianginl drgs: inc in dias int, dec in myocard contract force, incr cBflow, reduc invenous ret
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inc in total coronary blood flow
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B adren useful b/c a. attenu exercise induced tachy b. recuce cardiac contract c. relax venous sm muscle
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a and b only
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ca chan bloc drgs lk nifedipine a. lwr perip. resis; b. inhibit coron art spasm, rduc cardiac contract more than verap
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a and b
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F abt nitroglycerine? rduc myocar wk by dec pre/after load; high bioav, when diss in mthl
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both true
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F abt nitroglycerne? direct reuc cardiac rate,contr, relieves unstable angina due to inhib of pltlet aggreg
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directly redices cardia rt and cotnractility
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contrib to reduced mortality ht tx? int w/angiotensin II, ptl block of cardiac beta 1 adren rec, inc myocardial contract
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interference w/actions of angiotensin II, ptl blockade of cardiac beta 1 adrenergic receptors
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F re ACE inhib? reduce periph. resist;propote na excretion;increase glom, filt rate;redaldosterone;cough
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false: increase GFR
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F abt digitalis? margin of safely narrow; inhib Na/K Atpase in excitable cells; inc intracell Ca, reduce perif resis
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false: reduce peripheral vascular resistance
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which T? reg of liver LDL is dom mech for controlling LDL lvs; LDL antiatherogenic;lwring ldl no eff on coronary ht dis
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reg of liver LDL receptor levels most dom mech for controlling LDL levels in humans
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Zetia 1st drug choice for elev LDL lvs; binds to nucl recep of PPAR alpha; incr lipoprotein lipases, acts in smll intestine
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acts locally in small intestine
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preferably inhibits coagulation factor Xa: enoxaparin, streptokinase, warfine sodium, aspirin, abciximab
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enoxaparin
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Prevents binding of fibrinogen to glycoprotein IIb/IIIa receptors on platelets: enoxaparin, abciximab, strepto
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abciximab
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short acting form of this calcium channel blocker contraind, in pts with underlying coronary vasc. dis
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nifedipine
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an atagonist of AT1 subtype of angiotensin receptors, it blocks vacular, adrenal, and renal effects of the hormone
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losartan
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A venous and arterial vasodilator that is administered iv for HTN emergencies
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sodium nitroprusside
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an antagonist of beta adrenergic receptors
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propranolol
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this calcium channel blocker can bind to and inhibit both cardiac and sm. muscle L ca channels
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Dilitiazem
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A potassium sparing diretic that blcs sodium channels in collecting duct
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triameterine (dyrenium)
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acts in the proximal tubule to inhibit carbonic anhydrase
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Acetizikanude (diamox)
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inhibits N-K_cl2 co transportors in ascending loop of henly
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lasix
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relatively weak diuretic that reduces peripherak vasc resis and is oft 1st choice for tx of htn
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hydrochlorothyazide
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T or F: typical dose of beta adrenergic receptor antagonist used for init. tx of ht failure = to that used for init tx of htn
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T
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T or F: Lipitor selectively inhibits cholesterol absorption by enterocyts.
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F (inhibits HMGCoA)
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T or F: nicotinic acid inhibits rate limiting step in cholesterol biosyntheis
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F. Lipitor does
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