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22 Cards in this Set
- Front
- Back
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what not side effect of ACE inhib? cough, excessive aldostrone secretion, decrsed glomerular filt, hyperkalemia
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excessive aldosterone secretion
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when given in therap. doses: dig. glycosides:inhibit Na/k ATPas in all excit cells;inc Ca conc. in cardiac cells
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both
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contraind. in pts with MI: lidocaine, propafenone, amidarone, quinidine
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propafenone
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adenosine involves activation of: Na? Ca2? K?
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K+
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Class1 antirhthmic:dec action pot thresh, cause pos inotrop, used for supravent arryth, more effec in rap myocardium
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more effective in rapidly beating myocardium
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Class3 antiarrythmic drgs: incr efractoriness, specific K+channel blockers;inc QRS int; short vent act.ion potential
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increase refractoriness
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Whihc nonsystemic antacid? cimetidine, omeprazole, sucralfate, misoprostol, none
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none (only magnesium, aluminum, calcium salts)
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which competive antagonist at histamine H2?cimetidine, omeprazole, sucralfate, misoprostol, none
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cimetidine (Tagamet)
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noncomp inhib of porton pump;prodrug which needs acid?cimetidine, omeprazole, sucralfate, misoprostol, none
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omeprazole (prilosec)
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physically protects stomach by binding to damaged surf.cimetidine, omeprazole, sucralfate, misoprostol, none
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sucrulfate (carafate)
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inhibis vitamin k dep synthesis of clotting factors: heparin, streptokinase, warfin, aspirin, abcixmab
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warfin sodium (coumadin)
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blocks synthesis of thromboxane A2 in platelets:heparin,streptokinase, warfin, aspirin, abcixmab
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aspirin
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peferentially inhibis coagulation factor Xa heparin, streptokinase, warfin, aspirin, abcixmab
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heparin
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causes clot dissolution
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streptokinase (streptase)
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T or F: all antihypertensive drugs reduce art pressure by simultaneously reducing both CO and total peripher resis
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F
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T or F: nitroglycerine and sodium nitroprusside are prodrucs b/c gas nitric oxide is bioactive agent released
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T
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T or F: homozygous form of familial hypercholesterolemia is succeffully with Lipitor
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F
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T or F: According to fed law, schedule I drugs can only be prescribed for life threatening diseases
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F: (schedule I no acceptable med use)
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T or F: phase 1 clinical trials involve laboratory animal testing to assess safety and bioavailability of new drugs
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F: phase 1=20-80 healthy individ
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Tor F: FDA requires data demo bioavail , safety, and efficacy of new prescrip drugs b4 marketing
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T
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Tor F: drugs that have been shown to reduce mortality due to ht failure r those that inc contractile force eg. digitalis
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F: ACE inhibitors and AT-1 receptors reduce mortality
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T or F: beta blockers have a wide margin of safety when used for tx of ht failure
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F
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