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40 Cards in this Set
- Front
- Back
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statement that best describes neurotransmitters utilized by parasymp. nerves
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both pre and post ganglionic nerves release acet. choline
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where do sympathetic nerves arrise from?
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thoracic lumbar
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Are dobutamine and albuterol both selective agonists for subtypes of beta adrenergic receptors?
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yes
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how does trimetaphan lower blood pressure>
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inhibits nicotinic acetyl choline receptors tp block synaptic trasmission at autonomic gang
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Which drus are most dangerous to combine with binge eating of wine and cheese?
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MAO-Inhibitors
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Epi induces bronchodilation through which subtype of adrenergic receptor?
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beta 2
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Key functional diff between pusudo ephederine and methylphenidate
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methylphenidate crosses BBB whereas pseudoeph. doesn't
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Prazosin lowers blood pressure by
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blockade of alpha1 adrenergic receptors on blood vessels
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best treatment for pt suffereing from high symp. tone and persistent tremor of hands
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beta 1+beta 2 adrenergic receptor antagonist
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Resperine is used as a last resort for treatment of
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raynaud's syndrome
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for pt with acute hypertensive crisis, best drug choice:
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beta 1 and alpha 1 adrenergic antagonist
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T or FEffects of a a competitive antag are diminsh response to agonist, surrmountable, reversible
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True
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T or F: A partial agonist has rel low efficacy comp. to full agonist; can partially inhib resp to full agonist
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True
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The potency of the drug is
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the position of the dose-response curve on x axis
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Process by which most drugs absorbed from lumen of small int. across epi cellsi into venules draining organ
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passive lipid diffusion
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The apparent volume of dist. of a drug is best described as
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hypothetical volume that relates the plasma conc.of drug to amt of drug in body
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Form Vd=(Distribution volume)
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Vd=Vc(central compartment voluve)+Vp (Peripherial volume)
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Formula for drug clearance
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CL=rate of elimination/plasma concentration
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Which of following not needed to calc mean conc. of drug at steady state?half,CLP,Dosage rate, Bioavail (F)
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half life
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How does tubocurarine work?
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competitively blocks nicotinic acetylcholine receptors at neromuscular junction
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What favors reabsorption of drug that is a weak acid from proximal renal tubules.
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low urinary pH, high lipid solubililty of nonionized from of drug
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Which phase of metabolism requires a high energy cosubstrate?
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Phase II (Conjugation rxns)
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What does phase 1 metabolism do to the polarity of drug?
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increases polarity
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Can cytochromes P450 metabolize drugs in phase 1?
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Yes.
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For a drug that is inactivated by metabolism, inhib of its metabolism by a second drug will decrease its
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clearance
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T or F: CYP2D6 is respon for abt 1/4 of clinically avail drugs
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True
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T or F: CYP2D6 is found in the endoplasmic reticulum of cells
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True
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T or F: CYP2D6 uses NADPH as a cofactor to metabolize drugs
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True
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T or F: There is no known genetic mutation that affcts the activity of cytochrome P450 2D6
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False
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If drug metab by an enzyme that has genetic polymorphi, can pheotyping and geno. predic rsesp?
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No
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How does pilocarpine work?
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direct acting muscarinic acetylcholine receptor agonist (on eye for glaucoma)
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Atropine is a muscarinic
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antagonist
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Does neostigmine potentiate neurotransmission at all peripheral cholinergic junctions?
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yes
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Why are muscarinic acetylcholine receptor antagonist contraindicated in pts with glaucoma?
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increase intraocular pressure by reducing outflow of aqueous humor
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A common side effect of drugs with anti-muscarinic actions is
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increased heart rate
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T or F: An antagonist has an efficacy of zero
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True
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T or F: Ligand gated and Gprotein recept. most common targets for drugs
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T
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T or F: weak base will accum in fluids whose pH lower than pka
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T
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T or F: half-life of drug inversely prop. to its elimination rate
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T; T1/2=.693/Ke
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Take practice test 2007
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see test
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