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20 Cards in this Set
- Front
- Back
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Famciclovir
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nucleoside purine & pyrimidine analog, phosphorylated by viral thymidine kinase -> inhibits viral DNA polymerase
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acyclovir
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guanine analog phosphylated by viral thymidine kinase -> inhibits viral DNA polymerase (HSV, VZV)
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ganciclovir
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nucleoside analg phosphorylated by viral thymidine kinase -> inhibits viral DNA polymerase (CMV in HIV pts)
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foscarnet
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pyrophosphate analog (all herpes viruses... acyclovir resistant HSV/VZV, HIV)
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zidovudine (AZT)
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pyrimidine analog binds to reverse transcriptase blocking strand formation (NRTI)
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stavudine (D4T)
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pyrimidine analog binds to reverse transcriptase blocking strand formation (NRTI)
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Iamivudine (3TC)
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pyrimidine analog binds to reverse transcriptase blocking strand formation (NRTI)
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didanosine (DDI)
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pyrimidine analog binds to reverse transcriptase blocking strand formation (NRTI)
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Nevirapine
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allosteric inhibition of reverse transriptase (NNRTI)
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Delavirdine
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allosteric inhibition of reverse transriptase (NNRTI)
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efavirenz
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allosteric inhibition of reverse transriptase (NNRTI)
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maraviroc
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fusion inhibitor of CCR5 receptor on CD4 cells (resistant HIV strains)
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rifampin
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RNA polymerase inhibitor (TB, MRSA)
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ciprofloxacin
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DNA replication inhibitor: inhibits DNA gyrase or topoisomerase IV -> supercoiling (bacteria) (Fluoroquinolone)
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levofloxacin
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DNA replication inhibitor: inhibits DNA gyrase or topoisomerase IV -> supercoiling (bacteria) (Fluoroquinolone)
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metronidazole
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reduced under anaerobic conditions -> free radicals -> bacterial/protozoan DNA damage
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sorivudine
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pyrimidine nucleoside analog phosphylated by viral thymidine kinase -> inhibits viral DNA polymerase (immunocemp VZV)
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imiquimod
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topical immune-modulator that enhances native INF production
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cidofovir
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cytosine analog used in HPV
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oseltamivir
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neuraminidase inhibitor -> prevents viral release from host cells
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