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13 Cards in this Set
- Front
- Back
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What is aqueous diffusion?
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Enters through aqueous pores, esp in the kidneys
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What is lipid/passive diffusion?
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Directly passes through lipid bilayers, driven by concentration gradient
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What is carrier-mediated / active-transport?
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Movement of drug across membranes using drug transporters
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What 4 sites use active transport?
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Across neuronal membranes, choroid plexus, renal tubular cells and hepatocytes
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What is facilitated diffusion?
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Carriers that don't require energy transports water soluble things across membranes
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What is vesicular transport?
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Only used for large molecules
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What are properties of acidic drugs?
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Non ionized, protonized, proton DONOR
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What is the acid drug equation?
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pH - pKa = log (A-/HA)
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What are properties of basic drugs?
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Ionized, protonated, proton ACCEPTOR
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What is the basic drug equation?
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pH - pKa = log (B/BH+)
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What happens to weak acidic drugs in an acidic medium?
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Weak acidic drug is LESS ionized, more lipid soluble and rapidly ABSORBED
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What happens to weak basic drugs in an acidic medium?
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Weak basic drug is MORE ionized, will accumulate in the environment, wont absorb
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What happens to strong acids and strong bases?
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ALWAYS IONIZED, not lipid soluble and can't penetrate lipid membrane passively
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