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18 Cards in this Set

  • Front
  • Back
Antagonists of B - derivitve
- devitives of isoproterenol
Propranolol
- B1 and B2 blocker
- Bradycardia and a reduction of CO
- peripheral resistance initially is increased, but will lower BP if give chronically
- blood flow to most tissues is decreased
- F ~ 30%, due to major hepatic metabolism
Antagonists of B - uses
- V arrhythmias
- Angina pectoris
- Hypertension
- Cardiac myopathies
- Long-term prophylaxis after myocardial infarction
- Prophylaxis of migraine
- Hyperthyroidism
- Glaucoma
- for pheochromocytoma
- Acute fright/stress syndromes
• Skeletal muscle tremors
Metoprolol
- B1 antagonist
- for the treatment of hypertension
Esmolol
- B1 antagonist
- a very short duration of action compared to meteprolol
- use in IV infusion for short duration or for pts in which B-blockade might need to be withdrawn quickly
non-selective A blockers
drug-induced tachycardia has severely limited the clinical usefulness of molecules that antagonize both A1 and A2
Prazosin
- A2 antagonist
- used for hypertension and refractory heart disease
- doesnt block A1, so wont produce lots of tachycardia
Pindolol
- B1 and B2 antagonist
- is a partial agonist so may produce smaller reductions in resting HR than others
- good for hypertenisve pts w/ significant decreases in cardiac reserve or with a propensity for bradycardia
cause of migraines (our best guess)
release of serotonin both from platelets and from serotoninergic nerve terminals
Sumatriptan
- a 5HT1D serotonin receptor-selective agonist
- very effective for acute treatment of migraines
ergotamine
- ergot alkyloid
- is very effective during the prodrome of an attack
- afterwards, its less effective
propranolol trade name
Inderal
metoprolol trade name
(Lopressor)
esmolol trade name
(Brevibloc)
pindolol trade name
(Visken)
prazosin trade name
(Minipress)
sumatriptan trade name
(Imitrex)
ergotamine trade name
(Ergostat)