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18 Cards in this Set
- Front
- Back
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Antagonists of B - derivitve
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- devitives of isoproterenol
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Propranolol
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- B1 and B2 blocker
- Bradycardia and a reduction of CO - peripheral resistance initially is increased, but will lower BP if give chronically - blood flow to most tissues is decreased - F ~ 30%, due to major hepatic metabolism |
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Antagonists of B - uses
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- V arrhythmias
- Angina pectoris - Hypertension - Cardiac myopathies - Long-term prophylaxis after myocardial infarction - Prophylaxis of migraine - Hyperthyroidism - Glaucoma - for pheochromocytoma - Acute fright/stress syndromes • Skeletal muscle tremors |
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Metoprolol
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- B1 antagonist
- for the treatment of hypertension |
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Esmolol
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- B1 antagonist
- a very short duration of action compared to meteprolol - use in IV infusion for short duration or for pts in which B-blockade might need to be withdrawn quickly |
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non-selective A blockers
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drug-induced tachycardia has severely limited the clinical usefulness of molecules that antagonize both A1 and A2
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Prazosin
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- A2 antagonist
- used for hypertension and refractory heart disease - doesnt block A1, so wont produce lots of tachycardia |
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Pindolol
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- B1 and B2 antagonist
- is a partial agonist so may produce smaller reductions in resting HR than others - good for hypertenisve pts w/ significant decreases in cardiac reserve or with a propensity for bradycardia |
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cause of migraines (our best guess)
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release of serotonin both from platelets and from serotoninergic nerve terminals
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Sumatriptan
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- a 5HT1D serotonin receptor-selective agonist
- very effective for acute treatment of migraines |
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ergotamine
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- ergot alkyloid
- is very effective during the prodrome of an attack - afterwards, its less effective |
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propranolol trade name
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Inderal
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metoprolol trade name
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(Lopressor)
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esmolol trade name
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(Brevibloc)
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pindolol trade name
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(Visken)
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prazosin trade name
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(Minipress)
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sumatriptan trade name
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(Imitrex)
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ergotamine trade name
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(Ergostat)
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