Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/126

Click to flip

126 Cards in this Set

  • Front
  • Back
list the monoamines
dopamine
NE
serotonin
serotonin comes from
tryptophan
dopamine is found where
midbrain
too much dopamine causes
schizo
too little dopamine causes
parkinson's
NE is a nts in PNS and CNS. List the fxns
PNS - increase BP, vasoconstriction

CNS- arousal
gluatamate
excitatroy
GABA
inhibitory
aspartate
excitatory
huntington's caused by
too little GABA
mu receptor
PEAAR

pain relief
euphoria
anxiety relief
addiction
respiratory depression
kappa receptor
MASH

miosis
analgesic
sedation
hallucination
delta receptor
PED

pain relief
euphoria
dependence
name the opiod agonists
morphine
codine
methadone
heroin
meperidine
dextromethorphan
morphine

MOA
USE
agonist at mu, ka, delta

use: anxiety, pain, pulmonary edema, sickle cell crisis
MORPHINE and other opioid agonists side effects
MORPHINE

Miosis
Out of it --> sedation
Respiratory depression
Pain relief
Hypotension
Infreq urination & defecation
Nausea
Emesis
opioid agonist that is a cough suppresant and can be used for pain relief in combo with tylenol
codeine
what are sedative hypontics used for
insomnia tx; makes you go to sleep, sleep longer
CI of sedative hypnotics
sleep apnea
alcohol use
pregnancy
elderly
snoring
List 4 types of sedative hypnotics
Halcion (triazolam)
Restoril (temazepam)
Ambien
Antihistamines - Benadryl
which are the 2 BDZ used for sleeping
halcion (triazolam)
restoril (temazepam)
BDZ with long onset that doesnt cause daytime drowsiness but causes rebound REM and insomnia
Restoril (temazepam)

it RESTORes your insomnia
BDZ with short half life that has no daytime effect but can cause confusion
halcion (triazolam)

descanCIO = sleep

HALCION = hallucinations ie confusion
what is special about ambien
acts of BDZ binding site on GABA but isnt a BDZ
what are the side effects of ambien
drowsiness
drugged feeling
name the 2 major anti anxiety drugs, class, and MOA
-BDZ (end in am)
-Valium
-Xanax

modulates chloride channelss on GABA thereby increasing the hyperpol effect
why do valium and xanax do
treat anxiety so when you are anxious your are to excited thus you have to cure it by making you less excited by binding the INHIBITORY nts GABA
what things beside anxiety and panic attacks is valium and xanax used for
insomnia
sedative
alcohol withdrawl
what are the side effects of xanax and valium
drowsiness
sedation
dizzy
confused
poor coordination
what cant a BDZ be mixed with and why
alcohol because it will kill you!
what causes psychoses
too much dopamine
what is the goal of antipsychotic drugs
anatgonize dopamine receptors
List the antipsychotic drugs
chloropromazine
haloperidol
risperidone
clozapine
olanzapine
MOA of chloropromazine
block D2 recptor
MOA of haloperidol
block D2 receptor
which antipsychotic is more potent chloropromazine or haloperidol
haloperidol
visual side effects of D2 antagonists (chloropromazine/haloperidol)
dilation
side effect of D2 antagonists
sedation
urinary retention
blurred vision
Parkinson like effects
risperidone

moa
atypical antipsychotic
clozapine
atypical antipsychotic
D4 antagonists
olanzapine
atypical antipshychotic
atypical antipsychotic that causes granulocytosis and requires weekly WBC count
clozapine
atpical antipsychotic that causes wt gain and sedation
olanzapine
atypical antipsychotic that causes cardiac arrythmias by increasing prolactin
risperidone
what happens in parkinsons
dopaminergic neurons are loss in substania nigra

too little dopamine
loss of vol motor fxns
depression
Alzhiemer's dz
parkinson's dz
goal of parkinsons
increase dopa
replace dopa
dopa agonists
list the parkinson's drugs
SALAD

Selegline
Anticholinergics
L-dopa
Amantadine
Dopamine agonists
can dopamine cross BBB
NOPE
crosses BBB and is then converted to dopa; which drug is this
Levodopa
what is levodopa always given with
carbidopa
use of levodopa
parkinson's
levodopa side effects
arrythmias
nausea
vomitting
anorexia
psychotic problems
CI of levodopa
ANGLE CLOSURE GLAUCOMA
schizo
arrythmias
melanoma
antipsychotic drug that causes hyperpigmentation of RPE
chloropromazine
parkinson's symptoms
TRAP

Tremor at Rest
Akinesia
loss of Posture
carbidopa
DOESNT CROSS BBB

increased dopamine peripherly
carbidopa is always given with ___ as what
given as Sigemet with l-dopa
Sigemet
carbidopa given with l-dopa
why is carbidopa/sigemet given with l-dopa
decreases l-dopa side effects
bromocryptine
a dopamine 2 receptor agonist

CRYPTS smoke DOPE
MAOI inhibitor that decreases levodopa/dopa metabolism thus prolonging its effects
selegeline
side effects of selegeline
insomnia
atrial fibrilation
potentiates l-dopa
what the problem with MAOI
lots of drug interactions
Entacapone (comatan)
COMT inhibitor

works by increasing 3-methyldopa which competes with ldopa for a carries that carries l-dopa across BBB; methyldopa wins, ldopa not carried thus lasts longer
anticholinergic that blocks M Ach receptors to decrease rigidty and twitching
benztropine (congetin)

tropine like in atropine -- cholinergic antagonist
side effects of benztropine
opp of SLUD
Amantadine
antiviral used to decrease tremor and rigidity and bradykinesis in Parkinsons
list the 4 classes of anti-depressants
MAOI
TCAs
SSRI
Atypicals
phenelzine
MAOI
amitriptiline
TCA
prozac
SSRI
zoloft
SSRI
wellbutrin
atypical antidepressant
blocks breakdown of NE and Seorotonis in synaptic cleft to thereby increase these nts
MAOI --- phenelzine
MAOI side effecrs
hypotension
sedation
CNS stimulation
wt gain
sexual dysfxn
what can't be mixed with MAOI because it causes deadly hypertensive crises
tyramine - food like wine, meat, cheese
what happens if MAOI mixed with a TCA
hypertension
CNS toxicity
high fver
what happens when MAOI mixed with SSRIs
serotonin sickness
how does amitriptyline work
at first inhibits NE and/or serotonin reuptake but then down regulates adrenergic and serotonin receptors
what is amitriptyline used for
pain
migraine
sedation
fibromyalagia
side effects of amitriptyline (TCA)
anticholinergic
tachycardia
sedation
wt gain
ortho hypotension
sexual disfnx
TCA side effects
TCA'S

thrombocytopenia
cardio toxicity
anticholinergic
sexual dysfxn/seizures
TCA are ___ toxic
HIGHLY

cause death in overdose
what should u not take TCA with
alcohol
MAOI
cardio problems
MOA of SSRI
inhibit serotonin reuptake
DOC for depression
SSRI because lest side effects
does cause: HA, fatigue, insomnia, decrease libido
what should SSRI not be taken with
MAOI

serotonin syndrome
antidepressant that inhibits NE and DOPAMINE reuptake
wellbutrin
uses of wellbutrin
tobacco w/drawl
ADHD
depression
adavantage of wellbutrin over other antidepressants
no sexual dysfunction
list anticonvulsants
carbamazepine (tegretol)
phenytonin
phenobarbital
gabapentin (neurontin)
valproic acid
BDZ - lorazepam and diazepam (valium)
enhances GABA by acting on GABA a receptors and inhibits NE reuptake and sodium channels
carbamazzepine (tegretol)
phenytoin
DOC for partial seizures
tegretol
phenytoin
side effect of tegretol
nystagmus
ataxia
side effect of phenytoin
nystagmus
diplopia
gingival hyperplasis
ataxia
reduces glutaminergic transmission (glutamate is excitatory)
phenobarbital
increases GABA by affecting its synthesis, release, and reuptake
gabapentin (neurontin)
inhibits Ca current; blocks partial seizures
valproic acid
act on GABA receptor and used for status epilepsy
BDZ

lorazepam
diazepam
central acting muscle relaxants treat what
muscle spasm
CNS spasm
local acting muscle relaxants do what
act locally to block muscle contration and reduce spasms
NMJ blockers do what
muscle paralysis
name central acting drugs for spascity
diazepam
baclofen
name local acting drug for spasms
cyclbenzaprine
name MNJ blockers
succinylcholine
tubocurarine
diazepam and baclofen act on
GABA
cyclobenzarpine moa
deepress spinal polysynaptic reflexes
NMJ blockers block
nicotinic receptors
NMJ induce
muscle paralysis
decreased response to drug effects associated with dependence
tolerance
brains need and state of belieing that you need the drug
physiological dependence
body's dependancy on drug to survive; withdrawl symptoms without it
physical dependance
psycho and physical dependance
addiction
LSD
CNS hyperarousal
interacts with serotonin receptors in brain
what does LSD do to eyes
dilation
PCP (phencyclidine)
was an anesthetic that caused hallucinations
tobacco - nicotine
mimics Ach at preganglionic synapses in PAN and SAN
tx for smokers
wellbutrin
zyban
alcohol withdrawl tx
librium
lorazepam
clonidine
disulfuram
makes you physiclly ill when you consume alcohol
disulfaram
wernicke's syndrome
thiamine deficiecy causing brain damage in chronic alcholics
tx of wernickes
thiamine
opioid do what to eye
miosis
cocaine
blocks dopamine and Epi uptake in reward center in brain
cocaine tx
buprenorphine