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13 Cards in this Set
- Front
- Back
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MOA of INH
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structural cogener of B6 (pyridoxine), inhibits mycolic acids (compenents of mycobacterial cell walls)
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what TB drug is usually given for prophylaxis of TB
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INH
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neurotoxic effects of INH can be elieviated by adminitering what?
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B6 (pyridoxine)
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what genetic disorder is associated with hemolysis when taking INH?
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pts w/ glucose-6-phosphate dehydrogenase deffiency
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MOA of rifampin
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inhibition of DNA-dependant RNA polymerase
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major SE of rifampin
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induction of drug metabolizing liver enzymes, increasing the elimination of anticonvulsants, contraceptives, cyclosporine, ketoconazole, methadone, terbinafine, and warfarin
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MOA of ethambutol
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inhibition of arabinosyl transferase (arabinogalactan is a component of the mycobaterial cell wall)
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SE of ethambutol
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visual disturbances
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SE of pyrazinamide
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polyarthralgia, porphyria, hepatic dysfuntion, should not be used in pregnancy
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drug Tx for TB when INH resistance is suspected
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rifampin + pyrazinamide + ethambutol or streptomycin
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multi drug resistant TB can be treated with what drugs (based on susceptability)
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amikacin, ciprofloxacin, ofloxacin, ethionamide, p-aminosalicylic acid (rarely)
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usual drug Tx for M. leprae
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Dapsone, rifampin and clofazimine combination
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prophylaxis of MAC in AIDS pts w/ CD4 <50
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clarythromycin or azithromycin with or without rifabutin
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