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8 Cards in this Set
- Front
- Back
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Trimethoprim-sulfamethoxazole MOA
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Synergistic inhibition of folic acid synthesis; bacterialcidal; sequential blockade
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Trimethoprim-sulfamethoxazole Uses
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urinary tract, respiratory, ear, and sinus infections; P. jiroveci pneumonia, toxoplasmosis, nocardiosis
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Trimethoprim-sulfamethoxazole Tox
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Rash, high fever, bone marrow suppression, hyperkalemia, high incidence of adverse effects in AIDS
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Folate antagonists
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Sulfusoxazole, sulfadiazine, pyrimethamine, trimethoprim, pyrimethamine, sulfadoxine
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Folate antagonists MOA
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sulfonamides inhibit dihydropteroate synthase; trimethoprim and pyrimethamine inhibit dihydrofolate reductase
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Folate antagonists Uses
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simple urinary tract infections (oral) and topucal in burn or eye infections (sulfonamides); toxoplasmosis (sulfadiazine and pyrimethamine); malaria (sulfadoxine + pyrimethamine)
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Folate antagonists tox
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Common- oral does of sulfonamides cause GI upsets, acute hemolysis in G6PDh deficiency, possible crystalluria and rash (assume cross hypersenitivity)
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Ciproflaxins MOA
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Inhibits DNA replication by binding to DNA gyrase (gram-negative organisms) and topoisomerase IV (gram+); bacterialcidal
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