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8 Cards in this Set

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Trimethoprim-sulfamethoxazole MOA
Synergistic inhibition of folic acid synthesis; bacterialcidal; sequential blockade
Trimethoprim-sulfamethoxazole Uses
urinary tract, respiratory, ear, and sinus infections; P. jiroveci pneumonia, toxoplasmosis, nocardiosis
Trimethoprim-sulfamethoxazole Tox
Rash, high fever, bone marrow suppression, hyperkalemia, high incidence of adverse effects in AIDS
Folate antagonists
Sulfusoxazole, sulfadiazine, pyrimethamine, trimethoprim, pyrimethamine, sulfadoxine
Folate antagonists MOA
sulfonamides inhibit dihydropteroate synthase; trimethoprim and pyrimethamine inhibit dihydrofolate reductase
Folate antagonists Uses
simple urinary tract infections (oral) and topucal in burn or eye infections (sulfonamides); toxoplasmosis (sulfadiazine and pyrimethamine); malaria (sulfadoxine + pyrimethamine)
Folate antagonists tox
Common- oral does of sulfonamides cause GI upsets, acute hemolysis in G6PDh deficiency, possible crystalluria and rash (assume cross hypersenitivity)
Ciproflaxins MOA
Inhibits DNA replication by binding to DNA gyrase (gram-negative organisms) and topoisomerase IV (gram+); bacterialcidal