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11 Cards in this Set
- Front
- Back
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is the amount of time above the MIC important for aminoglycosides?
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no
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how are amino glycosides administered and why
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IV or IM because they are not absorbed oraly
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elimination of aminoglycosides is via what mechanism?
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glomerular filtration
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MOA of aminoglycosides
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bind to 30s subunit and block formation of the initiation complex, cause misreading of mRNA, and inhibit translocation
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major mechanism of resistance to aminoglycosides?
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plasmid mediated inactivating enzymes (group tansferases)
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aminoglycosides work better on aerobes or anareobes?
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areobes because penitration is partially oxygen dependant
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amino glycosides restricted to topical or oral uses?
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neomycin and kanamycin
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aminoglycoside -like drug used for the Tx of penicillin allergic gonorhea pts
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spectinomycin
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SE of amino glycosides
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ototoxicity (contraindicated in pregnancy), nephrotoxicity, neuromuscular blockade (reversable by Ca + neostigmine)
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most nephrotoxic aminoglycosides
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gentamicin and tobramycin
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amino glycosides used systemically
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gentamicin, amikacin, netilmicin, tobramycin
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