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11 Cards in this Set

  • Front
  • Back
Immunopharmacology Drugs
- 6 of them
- cyclosporine
- sirolimus
- prednisone
- cyclophosphamide
- methotrexate
- mycophenolate Mofetil
Purpose of Immunosuppressive drugs
- prevent organ rejection
- tx of autoimmune diseases
such as:
MS, lupus, rhuematoid arthritis, crohn's disease, typeI diabetes
Cell basis for rejection
- antigen presenting cell (from donor organ) activates Tcells
- T cells produce INTERLEUKIN 2
- IL2 stimulates production of immune cells
- activate immune cells attach the transplanted organ!
Molecular basis for rejection
- see pg 103 in notes
- IL-1 to the T cell
- Nuclear factor of activaed T cells (when this interacts with calcineurin, it can make IL-2 with is released and stimulates proliferation of immune cells
Prednisone
- works at molecular level
- blocks IL-1 from entering the T-cell and inhibits cytokine production
- adverse effects: insomnia, hypomania, ulcers
Cyclosporine
- block calcineurin from phosporylating NFAT
- adverse effects : nephrotoxicity, hepatotoxicity, neurotoxicity
Sirolimus
- blocks mTOR from signaling cell proliferation
- adverse effects; hyperlipidemia!
Cyclophophamide
Methotrexate
Mycophenolate
- these block cell proliferation after mTOR has already signaled
-mycophenolate; adverse effect- myelosuppression (proliferation associated toxicities)
Muromonab-CD3
(antibody)
- binds CD3 on surface of Tcells and inhibits function
- used to treat ACUTE TRANSPLANT REJECTION
Anti-IL-2 receport antibodies
(Daclizumab)
- blocks IL-2 receptor activation, thus blocking Tcell activation
- used to treat ACUTE TRANSPLANT REJECTION
Rh(D) immune globulin
- Rh(-) mother wil produce antibodies to Rh(+) baby's erythrocytes
- Rh immune globulin given to mother after birth
- this will lyse erythrocytes from baby before mother can generate an immune response