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36 Cards in this Set
- Front
- Back
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Phenytoin MOA
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Use-dependent Na channel block
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phenobarbital MOA
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Enhancement of GABA at GABAA-type channel (iontropic, Cl- conductive)
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carbamazepine MOA
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Sodium channel block: use-dependent block; limit high-frequency repetitive firing of action potentials
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ethosuximide moa
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Ca T-channel block
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valproate MOA
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Use-dependent Na channel block
Ca T-channel block |
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lorazepam moa
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Enhance GABA action at GABA-A receptors (ligand-gated Cl channels) by increasing the frequency of channel opening in presence of GABA (can't open channels in absence of GABA)
Selective for GABA-A heteromers that contain alpha-gamma subunit interfaces |
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diazepam MOA
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Enhance GABA action at GABA-A receptors (ligand-gated Cl channels) by increasing the frequency of channel opening in presence of GABA (can't open channels in absence of GABA)
Selective for GABA-A heteromers that contain alpha-gamma subunit interfaces |
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Clonazepam mOA
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Enhance GABA action at GABA-A receptors (ligand-gated Cl channels) by increasing the frequency of channel opening in presence of GABA (can't open channels in absence of GABA)
Selective for GABA-A heteromers that contain alpha-gamma subunit interfaces |
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gabapentin moa
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Block amino acid transport
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lamotrigine MOA
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Block N/P-type channels (which mediate transmitter release)
Also block Na+ high frequency firing |
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Tiagabine MOA
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block GABA uptake
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Topiramate MOA
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Enhancement of GABA at GABAA-type channel (iontropic, Cl- conductive)
Also blocks AMPA glutamate receptors |
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What drugs modulate Na+ opening?
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Carbamazepine
Phenytoin Valproate Lamotrigine Topiramate |
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What sort of seizures can phenytoin be used for?
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Tonic clonic seizures
Partial seizures |
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What sort of seizures can phenobarbital be used for?
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Tonic clonic seizures
Partial seizures |
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What sort of seizures is carbamazepine used for?
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Tonic clonic seizures
Partial seizures |
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What sort of seizures would you use ethosuximide for?
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Absence only seizures!
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What do you use lorazepam for?
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Status epilepticus; INITIAL TX!
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What do you use clonazepam for?
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Status epilepticus; INITIAL TX!
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What do you use Gabapentin for?
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Partial seizures
Neuropathic pain |
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What do you use lamotrigine for?
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All types of seizures
Bipolar disorder |
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What do you use diazepam for?
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Status Epilepticus; initial TX!
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What do you use tiagabine for?
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Partial seizures
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What do you use topiramate for?
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Tonic-Clonic
Partial Myoclonic, atonic Seizures Headache Off-label: Alcoholism |
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What is the course of Tx for status epilepticus?
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first: benzo
if still continue: Valproate or phenobarbital if still continue:general anesthesia: propofol, pentobarbital, isoflurane |
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What drug decreases bioavailability at higher doses
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Gabapentin
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Which drugs are highly bound to plasma proteins?
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Phenytoin, valproate, tiagabine, clonazepam
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How is Gabapentin eliminated?
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Renally
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How are most drugs eliminated?
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Liver
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What are the side effects of Phenytoin?
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Increased Seizure activity
Teratogenic Steven Johnson syndrome! |
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What are the side effects of Tiagabine?
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Increased Seizure activity
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What are the side effects of phenobarbital?
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Teratogen
Sedation Steven Johnson Syndrome |
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What are the side effects of valproate
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Teratogen and
1. GI: nausea, vomiting, anorexia (initial) 2. CNS: tremor 3. Thrombocytopenia 4. Hepatotoxicity |
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What drugs cause STeven johnson syndrome
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Phenytoin
Phenobarbital Carbamazepine Ethosuximide lamotrigine |
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What drugs cause metabolic enzyme induction?
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phenytoin
carbamazepine phenobarbital |
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What drugs cause metabolic Enzyme Inhibition?
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Valproate!
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