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18 Cards in this Set
- Front
- Back
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What is the MOA of Anti-psychotic (Neuroeptic) Drugs
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All agents competitively block dopamine receptors (D2). Newer agents also block serotonin receptors (5HT2). They can block muscarinic, alpha adrenergic, & histamine receptors in varying degrees.
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list the typical Anti-psychotic drugs (4)
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Low potency
-Chlorpromazine(Thorazine)-hiccups - Thioridazine (Mellaril)-1st sedative High potency - Fluphenazine (Prolixin)- injection - Haloperidol (Haldol) Gold standard |
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Which Anti-psychotic (Neuroeptic) Drugs can be used in preggos
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High potency
- Fluphenazine (Prolixin)- injection - Haloperidol (Haldol) Gold standard |
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What drug is a long acting Anti-psychotic IM inj. for pts requiring ext. action protocols
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Haloperidol deconoate
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What anti-emetic is used w/ antiphychotics
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Compazine
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most effective at positive symptoms (hallucination, delusions (persecutions, guilt and mind control), and bizarre behavior, combativeness, agitation.
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Typical (Traditional, OLD)
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Which category of anti psychotics are most effective at negative symptoms (social & emotional w/d, apathy, poor eye contact, poverty of speech)
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Atypical (New)
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What is the oldest & most effective antiphychotics agent, but high S/E. 2nd line agent used for schizophrenic pts resistant to other meds
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Clozapine (Clozaril)
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What are the S/E for Clozapine (Clozaril)
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black box warning -- agranulocytosis, fatal myocarditis, sedation, anti-cholinergic
-- monitored weekly; Q 2 wks if stable |
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1st line: prolactin elevation
Most used in children for psychiatric & behavioral disorders |
Risperidone (Risperdal)
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What drug is not FDA approved and causes Inc. risk of stroke in elderly
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Risperidone (Risperdal)
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32 y/o schizo pt gained 20lbs in 12 weeks and new onset diabetes. what med was she taking
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Olanzapine (Zyprexa)
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What drug is used in the Tx of nightmares and PTSD and can cause lens changes in long term Tx
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Quetiapine (Seroquel)
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DOC for Parkinson's
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Quetiapine (Seroquel)
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Which anti-psychotic Inc. QT interval and causes the least weight gain
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Ziprasidone (Geodon)
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What are the steps for Tx Pseudoparkinsonism
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Reduce dose of haloperidol
Change to atypical antipsychotic Give anti-cholinergic agent (DOC) |
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list the atypical Antipsychotic Drugs (5)
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Clozapine (Clozaril)
Olanzapine (Zyprexa) Quetiapine (Seroquel) Risperidone (Risperdal) Ziprasidone (Geodon) |
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list the Pseudoparkinsonism drugs (3)
(ABC) |
Trihexphenidal (Artane)- least sedating
Diphenhydramine (Benadryl)-most sedating Benztropine (Cogentin) - long duration |
