Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/15

Click to flip

15 Cards in this Set

  • Front
  • Back
Corticosteroids are useful in what types of inflammatoin
- acute
- delayed
- chronic
(NSAIDS only good for acute)
Corticosteriods to know for exam: BBDFHMPT
all end in "one"
- beclomethasone
- betamethasone
- dexamethasone
- fluticasone
- hydrocortisone
- methylprednisolone
- prednisone
- trimcinolone
Cortisol physiologic actions
- activates stress response
- activates cluconeogenesis and hyperglycemia
- Activates catabolism of proteins and lipids
- maintains vascular permeability
- maintains vascular contractility
Pharmalogical actions of cortisol
- only seen at high doses
- anti-inflammatory actions
- immunosuppressive actions
Limitations of natural and synthetic corticosteroid drugs
- metabolic effects
- sodium retention
- plasma protein binding
- metabolism
Inhaled corticosteroid benefits
- decreased airway inflammation and hyper-reactivity
- good local control
Inhaled corticosteriods
toxicity
- oropharyngeal candidiasis
- potential systemic toxicity when swallowed
-*minimize systemic toxicity by rapid metabolism in liver
Anti-inflammatory agents of Corticosteroids
- CS inhibit both the PLA2 and the COX-2
Glucocorticoids prevent tissue destruction associated with inflammation by:
- inhibiting activation of t-lymphocytes and macrophages
- inhibiting consequent secretion of the nonlysosomal proteolytic enzymes
Systemic toxicity of corticosteroid
- gluconeogenesis =diabetes
- catabolism of protein = osteoporosis, muscle weakness, poor wound healing, poor tissue repair
- susceptibility to infection
- Gastric ulcers
- cataracts
- growth suppression
- psychosis
Local toxicity of corticosteroid
- susceptibility to infection
- poor wound healing
Cushings disease is ...
- excessive action of cortisol
- Iatrogenic = drug induced
Iatrogenic Adrenal Insufficiency
- long-lasting nature of adrenal-pituitary suppression due to adrenal atrophy
- insufficiency can be induced by low doses due to negative feedback inhibition of pit.-adrenal function
Tx of iatrogenic adrenal insufficiency
- symptoms: decreased response to stress and hypotensino and shock
- 20mg/day prednisone for 1 month
Dose scheduling for corticosteroids (2 types)
- tapering = after thrapeutic response achieved, then a gradual reduction over 2-3 wks: prevents flare of inflammaroty process
- alternate day= reduces side effects in pts with long-term therapy, can preven adrenal-pituitary suppression