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33 Cards in this Set

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  • Back
MOA of NSAIDs
inhibit prostaglandin synthesis by inhibiting cyclo-oxygenase
difference between aspirin and other NSAIDs
aspirin irreversibly inhibits cyclooxygenase
Four main actions of NSAIDs
anti-inflammatory, analgesia, antipyretic, and antiplatelet activity
agent used for closure of PDA
indomethacin
aspirin is contraindicated in children with viral infection why
potential for development of Reye's syndrome- rapid liver degeneration and encephalopathy
SE of salicylates
tinnitus, GI bleeding
NSAID also available as an ophthalmic preparation
diclofenac
NSAID available orally, IM and ophthalmically
ketoralac
NSAID used for acute condition, such as pre-op anesthesia and has limited duration (<5 days) of use due to nephrotoxicity
ketoralac
NSAID that selectively inhibits COX-2
celecoxib
COX-2 inhibitors may have reduced risk of
gastric ulcers and GI bleeding
COX-2 inhibitors should be used cautiosly in patients with
pre-existing cardiac or renal disease
acetaminophen only has
antipyretic and analgesic activity
SE of acetaminophen
hepatotoxicity
antidote for acetaminophen toxicity
N-acetylcysteine
DMARDs are slow acting drugs for
rheumatic disease
MOA of gold salts
alter activity of macrophages and suppress phagocytic activity of PMNs
SE of gold salts
dermatitis of the mouth, aplastic anemia and agranulocytosis
causes bone marrow suppression
methotrexate
SE of penicillamine
aplastic anemia and renal
interferes with activity of T-lymphocytes
hydroxychloroquine
anti-malarial drug used in RA
hydroxychloroquine
SE of hydroxychloroquine
retinal destruction and dermatitis
MOA of leflunomide (newer agent)
inhibits dihydro-orotate dehydrogenase which leads to decreased pyrimidine synthesis
proteins that prevent action of TNF-alpha
infliximab and etanercept
anti-rheumatic agent also used for UC
sulfasalazine
anti-rheumatic agent also used for crohns disease
infliximab
NSAID used in gout
indomethacin
NSAID contraindicated in gout
Aspirin
MOA of chochicine
selective inhibitor of microtubule assembly
SE of colchicine
kidney and liver toxicity; diarrhea
agent used to treat chronic gout by increasing uric acid secretion
probenecid and sulfinpyrazone
allopurinol treats chronic gout by inhibiting
xanthine oxidase