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33 Cards in this Set
- Front
- Back
MOA of NSAIDs
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inhibit prostaglandin synthesis by inhibiting cyclo-oxygenase
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difference between aspirin and other NSAIDs
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aspirin irreversibly inhibits cyclooxygenase
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Four main actions of NSAIDs
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anti-inflammatory, analgesia, antipyretic, and antiplatelet activity
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agent used for closure of PDA
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indomethacin
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aspirin is contraindicated in children with viral infection why
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potential for development of Reye's syndrome- rapid liver degeneration and encephalopathy
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SE of salicylates
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tinnitus, GI bleeding
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NSAID also available as an ophthalmic preparation
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diclofenac
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NSAID available orally, IM and ophthalmically
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ketoralac
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NSAID used for acute condition, such as pre-op anesthesia and has limited duration (<5 days) of use due to nephrotoxicity
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ketoralac
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NSAID that selectively inhibits COX-2
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celecoxib
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COX-2 inhibitors may have reduced risk of
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gastric ulcers and GI bleeding
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COX-2 inhibitors should be used cautiosly in patients with
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pre-existing cardiac or renal disease
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acetaminophen only has
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antipyretic and analgesic activity
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SE of acetaminophen
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hepatotoxicity
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antidote for acetaminophen toxicity
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N-acetylcysteine
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DMARDs are slow acting drugs for
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rheumatic disease
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MOA of gold salts
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alter activity of macrophages and suppress phagocytic activity of PMNs
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SE of gold salts
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dermatitis of the mouth, aplastic anemia and agranulocytosis
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causes bone marrow suppression
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methotrexate
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SE of penicillamine
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aplastic anemia and renal
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interferes with activity of T-lymphocytes
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hydroxychloroquine
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anti-malarial drug used in RA
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hydroxychloroquine
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SE of hydroxychloroquine
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retinal destruction and dermatitis
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MOA of leflunomide (newer agent)
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inhibits dihydro-orotate dehydrogenase which leads to decreased pyrimidine synthesis
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proteins that prevent action of TNF-alpha
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infliximab and etanercept
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anti-rheumatic agent also used for UC
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sulfasalazine
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anti-rheumatic agent also used for crohns disease
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infliximab
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NSAID used in gout
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indomethacin
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NSAID contraindicated in gout
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Aspirin
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MOA of chochicine
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selective inhibitor of microtubule assembly
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SE of colchicine
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kidney and liver toxicity; diarrhea
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agent used to treat chronic gout by increasing uric acid secretion
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probenecid and sulfinpyrazone
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allopurinol treats chronic gout by inhibiting
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xanthine oxidase
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