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12 Cards in this Set
- Front
- Back
- 3rd side (hint)
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estrogen + progestin
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Hormone replacement therapy
promotes osteoclast apoptosis and inhibits osteoblast and osteocyte apoptosis |
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Raloxifene
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slective estrogen receptor modulator (SERM)
estrogen receptor agonist in bone and estrogen receptor antagonist in uterus and breast |
decreases risk of invasive breast cancer in postmenopausal women with osteoporosis
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alendronate
ibandronate pamidronate risedronate zoledronic acid |
biphosphonates
inhibits mevalonate pathway --> osteoclast apoptosis, decrease solubility of hydroxyapetite |
long term effect of profound inhibition of bone turnover unknown, Zoledronate administered IV only, Ibandronate available as monthly formulation
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Salmon calcitonin
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calcitonin
decreases osteoclast resorptive activity |
weak analgesic activity, nasal spray form used most widely, plicamycin man enhance hypocalcemic effect
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once daily PTH (1-34)
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bone anabolic agents
increases osteoblast differentiation and activity |
only approved bone-formation enhancing agent
induces osteosarcoma in long term rat studies |
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Fluoride
Strontium ranelate |
bone anabolic agents
increases osteoblast differentiation and activity |
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aluminum hydroxide
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oral phosphate binder
decreases absorption of dietary phosphate chronic kidney disease |
rarely used due to adverse effect profile
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calcium carbonate
calcium acetate |
oral phosphate binder
decreases absorption of dietary phosphate chronic kidney disease, osteoporosis, hypocalcemia, antacid |
calcium carbonate requires acidic environment for effective action, calcium acetate effective in acidic or alkaline environment
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sevelamer
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oral phosphate binder
decreases absorption of dietary phosphate chronic kidney disease |
also lowers serum cholesterol levels by binding bile acids
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calcifediol (25 OH D)
calcitriol (1,25OH2D3) cholecalciferol (vit D3) doxecaciferol (1aOHD2) ergocalciferol (vit D2) paricalcitol (19nor1,25OH2D2) |
vitamin D analogues
increase calcium absorption and decrease transcription of PTH gene |
calcitrol preferred aget if rapid therapeutic action desired, calitriol also used in treatment of vit D dependent rickets, paricalcitol may cause less hypercalcemia than calcitriol
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cinacalcet
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calcimimetic
increases sensitivity of calcium-sensing receptor to calcium in parathyroid gland chief cells, causing decreased secretion of PTH |
sometimes used off-label in treatment of primary hyperparathyroidism
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calcium gluconate
calcium carbonate |
calcium
essential for bone mineralization |
when administered IV, calcium gluconate causes less venous irritation
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