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7 Cards in this Set
- Front
- Back
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Acetylsalicylic Acid
ASPRIN |
- most widely prescribed NSAID
- IRREVERSIblE inhibition of COX |
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Salicylic Acid
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- similar to ASPRIN, BUT...
- REVERSIBLE INHIBITION of COX |
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Side effects of Salicylates
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- GI distress and bleeding
- prolongation of bleed time - condraindication in children with Pox or influenza - Salicylism: mild headache, dizziness, sweating severe- CNS disturbances, skin errucptions, fever, nausea |
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Non-salicylate drugs (3)
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- Ibuprofen
- Naproxen (long half life) - Indomethacin = used as antiinflammatory |
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COX 2 selective inhibitors
good ones |
- Nabumetone = converted to acidic metabolite in liver
- Celecoxib = much more selective for COX 2 |
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COX 2 selective inhibitors
UGLY! |
- Rofecoxib (vioxx)
- valdecoxib - even higher selectivity for COX 2 .. pulled because of CV events |
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ACETAMINOPHEN
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- USED FOR ANTI-PYRETIC AND ANALGESIC EFFECTS
- NOT ANITINFLAMMAORY AGENT!! - well tolerated and does not cause GI effects - high doses can cause hepatoxicity - tx overdose with acetylcysteine |
