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7 Cards in this Set

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  • Back
Acetylsalicylic Acid
ASPRIN
- most widely prescribed NSAID
- IRREVERSIblE inhibition of COX
Salicylic Acid
- similar to ASPRIN, BUT...
- REVERSIBLE INHIBITION of COX
Side effects of Salicylates
- GI distress and bleeding
- prolongation of bleed time
- condraindication in children with Pox or influenza
- Salicylism: mild headache, dizziness, sweating
severe- CNS disturbances, skin errucptions, fever, nausea
Non-salicylate drugs (3)
- Ibuprofen
- Naproxen (long half life)
- Indomethacin = used as antiinflammatory
COX 2 selective inhibitors
good ones
- Nabumetone = converted to acidic metabolite in liver
- Celecoxib = much more selective for COX 2
COX 2 selective inhibitors
UGLY!
- Rofecoxib (vioxx)
- valdecoxib
- even higher selectivity for COX 2 ..
pulled because of CV events
ACETAMINOPHEN
- USED FOR ANTI-PYRETIC AND ANALGESIC EFFECTS
- NOT ANITINFLAMMAORY AGENT!!
- well tolerated and does not cause GI effects
- high doses can cause hepatoxicity
- tx overdose with acetylcysteine