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10 Cards in this Set

  • Front
  • Back
Fibrinolytic system
- plaminogen converted to plasmin
- plasmin can digest fibrin in the clot and also fibrinogen in the plasma
Fibrinolytic Drugs - 2
Streptokinase mechanism
- it is antigenic
- acts indirectly - forms activator that converts plasminogien to plasmin (t1/2 is 23 min)
when is streptokinase used?
- MI primarily
- venous thromsosis
- P.E>
Alteplase mechanism
- tissue type plasminogen activator which activates plasminogen that is bound to fibrin (CLOT SELECTIVE!!)
- DNA technology makes this
- directly converts plasminogen to plasmin
- short half life (5-8min)
When is alteplase used?
- MI
- acute ischemic stroke and massive PE
- given IV
- can be used in pts likely to be allergic to streptokinase!
Antiplatelet drugs (3)
- Asprin
- Clopidogrel
- Ticlopidine
Mechanism of Asprin
- inhibits the synthesis of TxA2 (thromboxane A2) by irreversible acetylation of the enzyme cyclooxygenase (COX-1) in the platelets
Why use asprin?
- small dose can be used
- useful in the prevention of thrombo-embolic disorders
Clopidogrel and Ticlopidine
How do they work?
- inhibite ADP pathway of the platelets
- irreversibly block ADP receptors
- have no effect on prostaglandin formation and may be given with asprin
- used in pts getting a coronary stent
- may cause neutropenia