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10 Cards in this Set
- Front
- Back
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Fibrinolytic system
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- plaminogen converted to plasmin
- plasmin can digest fibrin in the clot and also fibrinogen in the plasma |
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Fibrinolytic Drugs - 2
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-Streptokinase
-Alteplase |
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Streptokinase mechanism
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- it is antigenic
- acts indirectly - forms activator that converts plasminogien to plasmin (t1/2 is 23 min) - NONCLOT SELECTIVE!!! |
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when is streptokinase used?
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- MI primarily
- venous thromsosis - P.E> |
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Alteplase mechanism
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- tissue type plasminogen activator which activates plasminogen that is bound to fibrin (CLOT SELECTIVE!!)
- DNA technology makes this - directly converts plasminogen to plasmin - short half life (5-8min) |
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When is alteplase used?
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- MI
- acute ischemic stroke and massive PE - given IV - can be used in pts likely to be allergic to streptokinase! |
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Antiplatelet drugs (3)
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- Asprin
- Clopidogrel - Ticlopidine |
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Mechanism of Asprin
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- inhibits the synthesis of TxA2 (thromboxane A2) by irreversible acetylation of the enzyme cyclooxygenase (COX-1) in the platelets
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Why use asprin?
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- small dose can be used
- useful in the prevention of thrombo-embolic disorders |
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Clopidogrel and Ticlopidine
How do they work? |
- inhibite ADP pathway of the platelets
- irreversibly block ADP receptors - have no effect on prostaglandin formation and may be given with asprin - used in pts getting a coronary stent - may cause neutropenia |
