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22 Cards in this Set
- Front
- Back
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alpha-adrenergic receptors
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EPI > NE >> ISO
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beta-adrenergic receptors
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mainly in heart
ISO > EPI >> NE |
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beta1-adrenergic receptors
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ISO > EPI = NE
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beta2-adrenergic receptors
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ISO > EPI >> NE
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alpha1-adrenergic receptors
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constriction of BV’s in response to cat’s
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alpha 2-adrenergic receptors
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on sympathetic nerve endings and mediate inhibition of NE release
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beta 1,2 and 3 molecular details
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G-proteins that activeate adenylyl cyclase
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alpha 1 molecular details
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activate phospholipase C, mobilize Ca2+, and open PM Ca2+ channels
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alpha 2 molecular details
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activate Gi, to inhibit adenylyl cyclase and to activate K+ channels
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arterioles and skin -
innervation and effects |
- alpha
- NE and EPI constrict |
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bronchial SM
innervation and effect |
- B2
- EPI relaxes, NE has little effect |
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liver and SkM
innervation and effect |
- more B2 than A
- EPI relaxes, but NE constricts w/ the little A that's there |
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effect of NE on the heart
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- heart is B1 innervated so NE increases force and HR
- but when BP increases, there is a para relase of AcH onto the heart to slow it (vagal reflex) |
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desensitization
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- give B agonsist to relax bronchial SM
- may become desensitized |
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supersensitivity
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- B antagonist blocks NE
- but when its take away, there are more NE receptors, so more sensitive to NE now - typical withdrawl symptoms |
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EPI on BP and heart
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- inc contractility, systolic BP, mean BP and HR
- dec peripheral R and diastolic BP - dilate SkM arterioles |
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NE on BP and heart
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- inc contractility, systolic BP, diastolic BP, periperal resistance
- dec HR - constrics vasculature of ab organs, skin, and SkM |
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ISO on BP and heart
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- inc contractility, systolic BP, HR
- dec periperal R and diastolic BP - dilates arterioles of ab organs and SkM |
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clonidine
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- A2 agonist - anti-hpyertensive
- activates hypo to decrease symp outflow to SM vascualter to dec BP more - also used for withdrawal from narcotic addiction |
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cat metabolic effects
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- generally from cAMP
- mobilizes carbs and lipids -> hyperglycemia, inc lactic acid and free fatty acids in blood |
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cAMP molecular detail
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- activates a PK that activates phosphorylase b to a
- that causes breakdown of glycogen to glucose-1-phospatase and inactivates glycogen synthase |
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clonidine generic names
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(catapres, Duraclon)
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