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22 Cards in this Set

  • Front
  • Back
alpha-adrenergic receptors
EPI > NE >> ISO
beta-adrenergic receptors
mainly in heart
ISO > EPI >> NE
beta1-adrenergic receptors
ISO > EPI = NE
beta2-adrenergic receptors
ISO > EPI >> NE
alpha1-adrenergic receptors
constriction of BV’s in response to cat’s
alpha 2-adrenergic receptors
on sympathetic nerve endings and mediate inhibition of NE release
beta 1,2 and 3 molecular details
G-proteins that activeate adenylyl cyclase
alpha 1 molecular details
activate phospholipase C, mobilize Ca2+, and open PM Ca2+ channels
alpha 2 molecular details
activate Gi, to inhibit adenylyl cyclase and to activate K+ channels
arterioles and skin -
innervation and effects
- alpha
- NE and EPI constrict
bronchial SM
innervation and effect
- B2
- EPI relaxes, NE has little effect
liver and SkM
innervation and effect
- more B2 than A
- EPI relaxes, but NE constricts w/ the little A that's there
effect of NE on the heart
- heart is B1 innervated so NE increases force and HR
- but when BP increases, there is a para relase of AcH onto the heart to slow it (vagal reflex)
desensitization
- give B agonsist to relax bronchial SM
- may become desensitized
supersensitivity
- B antagonist blocks NE
- but when its take away, there are more NE receptors, so more sensitive to NE now
- typical withdrawl symptoms
EPI on BP and heart
- inc contractility, systolic BP, mean BP and HR
- dec peripheral R and diastolic BP
- dilate SkM arterioles
NE on BP and heart
- inc contractility, systolic BP, diastolic BP, periperal resistance
- dec HR
- constrics vasculature of ab organs, skin, and SkM
ISO on BP and heart
- inc contractility, systolic BP, HR
- dec periperal R and diastolic BP
- dilates arterioles of ab organs and SkM
clonidine
- A2 agonist - anti-hpyertensive
- activates hypo to decrease symp outflow to SM vascualter to dec BP more
- also used for withdrawal from narcotic addiction
cat metabolic effects
- generally from cAMP
- mobilizes carbs and lipids -> hyperglycemia, inc lactic acid and free fatty acids in blood
cAMP molecular detail
- activates a PK that activates phosphorylase b to a
- that causes breakdown of glycogen to glucose-1-phospatase and inactivates glycogen synthase
clonidine generic names
(catapres, Duraclon)