Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
55 Cards in this Set
- Front
- Back
|
Carbonic Anhydrase Inhibitors
|
Acetazolamide
Brinzolamide Dorzalamide Hyperkalemia, Acidosis, Glaucoma |
|
|
Loop Diuretics
|
Furosemide
Ethacrynic Acid High efficiency! Hypokalemia, ALKalosis, Hypocalcemia, Hypomagnesia, HYPERuricemia Edema due to CHF, renal failure Pulmonary congestion Ototoxicity |
|
|
Thiazides
|
Hydrochlorothiazide
Metolazone Indapamide Inhibit sodium reabsorption in distal tubule Hypokalemia, hyperuricemia Hyperlipidemia, hyperglycemia Blood dyscrasia, lithium toxicity, jaundice *Indapamide has no effect on lipids or glucose tolerance |
|
|
Direct inhibitors of Na flux
|
Amiloride
Triamtrene |
|
|
Aldosterone antagonists
|
Spironolactone
Eplerenone Potassium sparing Promote excretion of Na, retention of K+ Gynecomastia Epelerone - more selective, no endocrine effects, but has many drug interactions (CYP) that increase risk of hyperkalemia |
|
|
Osmotic Diuretic
|
Mannitol
|
|
|
ADH Agonists
|
Vasopressin
Desmopressin |
|
|
ADH Antagonists
|
Conviaptan
Demeclocycline Lithium Hyponatremia |
|
|
Vasodilatos that act through NO
|
Hydrazaline
Nitropress |
|
|
Vasodilators that act by opening K+ channels
|
Minoxidil
Diazoxide |
|
|
D1 agonist
|
Fendolpam
|
|
|
Ca channel blockers
|
Verapamil - strongest cardiac effects
Diltiazem Dihydropyridines - strongest vasodilators |
|
|
ACE Inhibitors
|
Catopril
Enalapril |
|
|
Angiotensin Receptor Antagonist
|
Losartan
|
|
|
a2 agonists
|
Clonidine
Methyldopa |
|
|
a1 antagonists
|
Prazosin
Doxazosin Terazosin |
|
|
B blockers
|
Propanolol
Metroprolol Atenolol Nebivolol Pindolol Acetabulol Bisoprolol |
|
|
Combined aB blockers
|
Labetalol
Carvedilol |
|
|
Sympathomimetrics used in CHF
|
Dobutamine
Dopamine |
|
|
Class I Antiarrythmic Agents
|
Sodium channel blockers
|
|
|
Class II Antiarrythmic Agents
|
Beta blockers
|
|
|
Class III Antiarrythmic Agents
|
Potassium channel blockers - Amiodarone, Sotalol, increase ERP
|
|
|
Class IV Antiarrythmic Agents
|
Ca channel blockers
|
|
|
Misc. Antiarrythmic Agents
|
Adenosine
Magnesium Potassium Digoxin |
|
|
Class Ia Antiarrythmic Agents
|
Block activated sodium channels, lengthen ERP - Quinidine
|
|
|
Class Ib Antiarrythmic Agents
|
Block inactivated sodium channels - Lidocaine
|
|
|
Class Ic Antiarrythmic Agents
|
Block all channels - Flecainide
|
|
|
Vasodilators - Nitrates
|
Nitroglycerin
Isosorbide |
|
|
Vasodilators - PDE inhibitors
|
Sildenafil
Vardenafil - less visual disturbances, faster onset Tadalafil - no visual disturbances, longer duration |
|
|
Vasodilators - other
|
Ranolazine - fatty acid oxidation inhibitor
Bosentan - endothelin receptor antagonist |
|
|
Niacin
|
Inhibits VLDL release from liver
|
|
|
Fibrates
|
PPAR-a antagonists, promote lipid metabolism
|
|
|
Cholestyramine
|
Bile acid binding resin - prevent bile acid reabsorption from gut, increase LDL receptor expression
|
|
|
Lovastatin
|
HMG-CoA reductase inhibitor, increase LDL receptor expression
|
|
|
Ezetimibe
|
Blocks intestinal absorption of cholesterol
|
|
|
Orlistat
|
Inhibits pancreatic lipase/aborption of TAGs in intestine
|
|
|
a2
|
Decreases cAMP
Presynaptic nerve terminals, lipocytes |
|
|
a1
|
Increase IP3, Ca
Smooth muscle of splanchnic, cutaneous blood vessels |
|
|
B1
|
Increase cAMP
Heart, renin release |
|
|
B2
|
Increase cAMP
Everywhere else |
|
|
B3
|
Increase CAMP
Adipocytes |
|
|
M1
|
Neurons
Increase IP3, Ca |
|
|
M2
|
Decrease cAMP
Heart |
|
|
M3
|
Increase IP3, Ca
Everywhere else |
|
|
D1,5
|
Increase cAMP
Brain, kidney blood vessels |
|
|
D2,3,4
|
Decrease cAMP
Brain |
|
|
Substances that inhibit NE release from sympathetic nerves
|
ACh(M2), NE/E(a2), Serotonin, Adenonsine, PGE, Histamine, Enkephalin, Dopamine (D2), ATP
|
|
|
Substances that facilitate NE release from sympathetic nerves
|
Adrenaline (B2), ATII
|
|
|
PDE inhibitor used in CHF
|
Inamrinone
|
|
|
BNP analog
|
Nesirtide
Improves PCWP and other CHF symptoms |
|
|
Drugs used in hypertensive emergencies
|
Nitropress, Fendolpam, Diazoxide
|
|
|
Hydrazaline
|
Dilates arterioles via NO
Chronic hypertension Used in combination with isosorbide dinitrate |
|
|
Nitropress
|
Dilates veins & arteries
Can cause cyanide toxicity |
|
|
Used for male pattern baldenss
|
Monoxidil
|
|
|
What you need to know about amiodarone
|
Half-life of 10-100 days!
|
