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72 Cards in this Set
- Front
- Back
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What is Anastrozole?
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A third generation, Aromatase inhibitor used in postmenopausal women with breast cancer
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What is Azathioprine?
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Purine- immunosuppresive.
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What is bisacodyl used for?
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Increase motility
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What is bleomycin?
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Antibiotic- oxidative DNA damage (G2 phase specific)
Tx- Testicular, Hodgkin's, squamous cell, ovarian, bladder |
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What is Bortezomib?
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Proteasome inhibitor- Multiple myeloma.
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What is cromolyn?
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Asthma- mast cell stablizer
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What is cyclosporin?
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Immunosuppressive drug- inhibits calcineurin, thereby decreasing T-cell activation.
-Transplantation and autoimmune disorders |
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What is cyproterone?
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Anti androgen- prostate cancer.
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What is cytarabine and what is it used for?
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Pyrimidine antagonist-->inhibits DNA polymerase, (S-phase specific)
AML, ALL, Non-hodgkin's lymphoma |
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What is daclizumab?
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An antibody against the IL-2 receptor of lymphocytes which is used in kidney transplantation.
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What is dactinomycin?
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Intercalates DNA- Childhood tumors
First cancer antibiotic |
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What is docetaxel?
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A taxane that interfers with microtubule formation and is used to treat a variety of solid tumors.
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What is domperidone?
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D2 antagonist- anti-emetic
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What is doxorubicin?
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An anthracycline with a broad spectrum of therapeutic uses against cancers.
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What is efalizumab?
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An antibody against CD11a present on leukocytes
Immunosuppressant |
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What does zafirlukast do?
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Asthma
Leukotrene receptors |
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What is erlotinib?
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A protein kinase inhibitor that specifically inhibits epidermal growth factor receptor (EGFR) and is used as a second choice in lung cancer.
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What is etoposide?
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Inhibits Topoisomerase II-->DNA breaks.
Small cell carcinoma of lung and prostate |
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What is 5-fluorouracil?
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Pyrimidine, inhibits thymidylate synthase and is incoporated into DNA.
Solid tumors. |
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What is special about 5-fluorouracil?
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Cell cycle non-specific- thymidylate synthase inhibition which could affect RNA synthesis during all phases of the cell cycle.
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What is fluvestrant?
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A pure anti-estrogen used to treat breast cancer by blocking estrogen receptors.
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What is foscarnet?
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pyrophosphate- VIRAL DNA polymerase
CMV, herpesvirus and HIV. |
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What is fulvestrant?
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SERD for breast cancer.
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What is gefitinib?
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Protein kinase inhibitor- EGFR
Second choice for lung cancer. |
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What is gemcitabine?
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Pyrimidine analog incorporated into DNA
Solid and metastatic tumors. |
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What is goserelin?
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GnRH- decreases estrogen, breast cancer
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What is infliximab?
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An antibody against TNF-alpha used to treat Rheumatoid arthritis and Crohn's Disease
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What is irinotecan?
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topoisomerase I inhibitor
colon cancer. |
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What is leuprolide?
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GnRH
Tx- Breast and prostate cancer. |
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What is lomustine?
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Analogous to carmustine, it is an alkylating agent (nitrosourea) which crosses into the CNS and thus can be used to treat brain tumors.
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What is loperamide?
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Diarrhea- decreases motility and secretion
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What is meclizine?
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An H1 receptor blocker (motion sickness) with some CNS side effects.
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What is megestrol?
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A steroidal androgen receptor blocker used in treating prostate cancer.
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What is methotrexate?
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A folic acid analog that inhibits dihydrofolate reductase, thereby disrupting thymidine synthesis. It is used to treat cancers and leukemias.
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What is metoclopromide?
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D2 antagonist- GERD and vomiting
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What is misoprostol?
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A synthetic analog of PGE1, increases mucous, decreases acid, which prevents NSAID peptic ulcers.
Maintains PDA (patent ductus arteriosus) |
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What is montelukast?
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Asthma- block leukotriene receptors, good for aspirin induced asthma
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What is muromonab?
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An antibody against peripheral CD3+ T-cells used in kidney transplantation.
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What is a significant drug interaction for omeprazole?
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It inhibits CYP2C19 thereby increasing warfarin and cyclosporin.
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What is ondansetron?
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A 5-HT3 antagonist. Anti-emetic
postoperative and chemotherapy vomiting You will not vomit with ONDANSetron, so you can go ON DANCing. |
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What is paclitaxel?
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Inhibits microtubule formation
Solid tumors (ovarian and breast) |
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What is paregoric?
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A drug used to treat severe diarrhea.
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What is pentamidine used for?
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To treat Pneumocystis jirovecki, Leishmaniasis, and trypanosomiasis.
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What is prednisone?
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A glucocorticoid that inhibits lymphocytes and is used to treat lymphocytic leukemias (ALL, CLL, Hodgkin's, MM).
Inhibits synthesis of all cytokines 1st line- chronic asthma |
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What is procarbazine?
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AA- Hodgkin's and brain tumors.
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What is procarbazine?
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It is a mono-functional alkylating agent (mehtylhydrazine class) used in Hodgkin's and brain tumors.
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What is procarbazine?
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AA
Hodgkin's and brain tumors. |
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What is a possible drug interaction of ranitidine?
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Ranitidine inhibits CYPs, Warfarin
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What is salmeterol?
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A long-acting beta-2 selective agonist used in treating asthma. Long acting for prophylaxis
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What is teniposide?
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Topoisomerase II
ALL and solid tumors |
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What is terbutaline?
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Beta 2 selective agonist- delay premature labor and asthma
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What is temsirolimus?
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A protein kinase inhibitor.
Renal Cell carcinoma |
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What does topotecan do?
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Topoisomerase I- Ovarian and breast cancer.
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What two very different scenarios might thalidomide be used for?
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Multiple myeloma
Leprosy |
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What does theophylline do?
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It causes bronchodilation by inhibiting cyclic nucleotide phosphodiesterase (cAMPase/cGMPase) and antagonizing adenosine receptors.
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What is vincristine?
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Inhibits formation ofmitotic spindle in M-phase.
Hodgkin's |
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What does vorinostat do?
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HDAC- Cutatneous T cell lymphomas
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What does zafirlukast do?
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It antagonizes leukotriene receptors (cys-LT1), causing bronchodilation useful in treating asthma.
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What is zileuton?
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Asthma- inhibit lipoxygenase and leukotriene synthesis
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What is zalcitabine used for?
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HIV- nucleoside
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What is zidovudine used for?
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HIV- nucleoside
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Cyclophosphamide
Mech Tx |
Mech- nitrogen mustard Alkylating Agent, DNA at guanine N7
Tx- most widely used AA: Non hodgkin's lymphoma, breast, ovary |
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What is Mechlorethamine?
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Nitrogen mustard- Hodgkins, lymphomas
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What is Chlorambucil?
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Slowest acting NM- CLL
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What is Busulfan?
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AA- CML
Toxicity- seizures, pulmonary fibrosis |
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Streptozocin
Tx Toxicity |
Tx- Pancreatic tumors
Toxicity- LOW myelosuppressive effect! Renal toxicity is dose limiting! |
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Thiotepa
Mech Tx |
AA
Tx- bladder |
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What is melphalan?
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AA- Multiple myeloma
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Cisplatin
Tx Tox |
Tx- solid tumors, testicular, ovary
Tox- renal |
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Oxaliplatin
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3rd generation, newest!
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Ifosfamide
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CYP34A cyclophosphamide- intercalate DNA at guanine N7
Tx- Non Hodgkins, breast and ovarian carcinomas, immunosuppresants Toxicity- Neurotoxicity, Hemorrhagic cystitis- prevented by mesna More toxic than cyclophosphamide |
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What is Imatinib?
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Mech- Protein kinase inhibitor
GI tumorsm Philadelphia chromosome- CML |
