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24 Cards in this Set
- Front
- Back
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Most frequent route of metabolism
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hepatic enzymes
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mechanisms of action for phenytoin, carbamazepine, lamotrigine
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sodium blockade
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MOA for benzodiazepines and barbiturates
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GABA-related targets
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MOA for ethosuximide
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calcium channels
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MOA for valproic acid at high doses
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affect calcium, potassium, and sodium channels
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DOC for generalized tonic-clonic and partial seizures
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valproic acid and phenytoin
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DOC for febrile seizures
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phenobarbital
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DOC for absence seizures
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ethosuxamide and valproic acid
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DOC for myoclonic seizures
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valproic acid
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DOC for status epilepticus
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IV diazepam for short term (acute) treatment; phenytoin for prolonged therapy
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drugs that can be used for infantile spasms
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corticosteroids
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anti-seizure drugs used also for bipolar affective disorder
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valproic acid, carbamazepine, phenytoin and gabapentin
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anti-seizure drugs used also for trigeminal neuralgia
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carbamazepine
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anti-seizure drugs also used for pain of neuropathic
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gabapentin
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anti-seizure agent that exhibits non-linear metabolism, highly protein bound, causes fetal hydantoin syndrome, and stimulates hepatic metabolism
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phenytoin
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SE of phenytoin
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gingival hyperplasia, nystagmus, diplopia and ataxi
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anti-seizure agent that induces formation of liver drug-metabolism enzymes, is a teratogen and can cause craniofacial anomalies and spina bifida
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carbamazepine
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agent that inhibits hepatic metabolism, is hepatotoxic and teratogen that can cause neural tube defects and GI distress
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valproic acid
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lab value required to be monitored for patients on valproic acid
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serum ammonia and LFTs
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SE for lamotrigine
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Stevens-Johnson syndrome
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SE for felbamate
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aplastic anemia and acute hepatic failure
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anti-seizure medication also used in prevention of migraines
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valproic acid
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carbamazepine may cause
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agranulocytosis
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antiseizure drugs used as alternative drugs for mood stabilization
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carbamazepine, gabapentin, lamotrigine, and valproic acid
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