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14 Cards in this Set

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  • Back
Morphine
opioid receptor agonist
MOA: inhibition of adynylyl cyclase (dec cAMP, increase K conductance)
SE: respiratory depression, inc. intracranial pressure, N/V
Vaso dilator, metabolite more potent so adds to anaglesia
Meperidine
opioid receptor agonist
MOA: inhibition of adynylyl cyclase (dec cAMP, increase K conductance)
SE: respiratory depression, inc. intracranial pressure, N/V
inc. oral potency, less resp. depression, DOC for OB
Methadone
opioid receptor agonist
MOA: inhibition of adynylyl cyclase (dec cAMP, increase K conductance)
SE: respiratory depression, inc. intracranial pressure, N/V
very long 1/2, used in treatment of heroin addiction and opioid withdrawal
Fentanyl
opioid receptor agonist
MOA: inhibition of adynylyl cyclase (dec cAMP, increase K conductance)
SE: respiratory depression, inc. intracranial pressure, N/V
80X more potent than morphine, muscular rigidity, TD patch
Codeine
opioid receptor agonist
MOA: inhibition of adynylyl cyclase (dec cAMP, increase K conductance)
SE: respiratory depression, inc. intracranial pressure, N/V
analgesic effect via metabolism to morphine, w/ NSAIDs for cough
Oxycodone
opioid receptor agonist
MOA: inhibition of adynylyl cyclase (dec cAMP, increase K conductance)
SE: respiratory depression, inc. intracranial pressure, N/V
=potent, inc. oral avail than morphine, combo w/ NSAIDs (oxycontin)
Propoxyphene
opioid receptor agonist
MOA: inhibition of adynylyl cyclase (dec cAMP, increase K conductance)
SE: respiratory depression, inc. intracranial pressure, N/V
1/2 potent as codeine, can have toxic build-up, cause irritation through IV
Pentazocine (Talwin)
Mixed opioid agonist/antagonist
MOA: Mu R antagonist, kappa R agonist
SE: less resp. depression, increased HR, BP, catecholamines
Nalbuphine (Nubain)
Mixed opioid agonist/antagonist
MOA: Mu R antagonist, kappa R agonist
SE: less resp. depression, increased HR, BP, catecholamines

unique in this class as doesn't exhibit significant cardiac effects
less likely to produce dysphoric effects
Butorphanol (Stadol)
Mixed opioid agonist/antagonist
MOA: Mu R antagonist, kappa R agonist
SE: less resp. depression, increased HR, BP, catecholamines
nasal spray
Buprenorphine (Buprenex)
Mixed opioid agonist/antagonist
MOA: Mu R antagonist, kappa R agonist
SE: less resp. depression, increased HR, BP, catecholamines
slow onset, long duration
Naloxone (Narcan)
Opioid Antagonists
MOA: blocks opioid R's (Mu best)
Gold standard, Tx or eval of opioid OD
used for neonatal resp. depression and mother takes opioids
Naltrexone (Trexan, Revia)
Opioid Antagonists
MOA: blocks opioid R's (Mu best)
higher oral efficacy than Naloxone
used as oral maintenance of opioid addicts, alcoholism
Antitussive/Antidiarrheal opioids
Codeine: depresses medulla cough center
Dextromethorphan: depresses medulla cough center
Diphenoxylate: depresses medulla cough center
Loperamide: no CNS effects