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12 Cards in this Set

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  • Back
Chemotherapy for the treatment of a Brain tumor, a class of drug that acts to cross-link DNA strands, inhibiting DNA synthesis
carmustine & lomustine
Chemotherapy for the a pancreatic islet cell carcinoma, a class of drug that acts to cross-link DNA strands, inhibiting DNA synthesis
streptozocin
A patient is admitted for hemturia with a history and current treatment of breast cancer. What chemotherapy agent might be causing this?
Cyclophosphamide
Chemotherapy for the treatment of non-Hodgkin lymphoma, a class of drug that acts to cross-link DNA strands, inhibiting DNA synthesis
cyclophosphamide
Chemotherapy for the treatment of testicular cancer, that is converted from its prodrug form by P450 in the liver, displays a long half-life, and is taken orally.
Ifosfamide
Chemotherapy for the a treatment of Hodgkin lymphoma, as well as topically for T-cell lymohomas. acts by cross-linking DNA strands
mechlorethamine
Chemotherapy for the treatment of bladder cancer. may lead to ototoxicity.
cisplatin
Chemotherapy for the treatment of genitourinary tumores, lung cancer, and head/neck cancer. It is inorganic, and is activated by water to its hydrated intermediate which then covalently binds to neutrophilic sites on guanine.
cisplatin
Chemotherapy for the treatment of gastic and colorectal cancers. Main side effects of this DNA cross-linking drug include neurotoxicity and neutropenia.
oxaliplatin
chemotherapeutic agent used in the treatment of gastric and colorectal caners by cross-linking DNA. May lead to neurotoxicity and neutropenia.
oxaliplatin
chemotherapy administered via IV for the treatment of Hodgkin's lymphoma and malignant melanoma. This prodrug is ativated by hepatic cytochromes and creates DNA cross-links.
dacarnazine
Chemotherapy used in the treatment of malignant gliomas in combination with radiation therapy. It is taken orally and undergoes nonenzymatic activation at physiologic pH so it can cause DNA cross-linkages.
temozolomide