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12 Cards in this Set
- Front
- Back
Chemotherapy for the treatment of a Brain tumor, a class of drug that acts to cross-link DNA strands, inhibiting DNA synthesis
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carmustine & lomustine
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Chemotherapy for the a pancreatic islet cell carcinoma, a class of drug that acts to cross-link DNA strands, inhibiting DNA synthesis
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streptozocin
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A patient is admitted for hemturia with a history and current treatment of breast cancer. What chemotherapy agent might be causing this?
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Cyclophosphamide
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Chemotherapy for the treatment of non-Hodgkin lymphoma, a class of drug that acts to cross-link DNA strands, inhibiting DNA synthesis
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cyclophosphamide
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Chemotherapy for the treatment of testicular cancer, that is converted from its prodrug form by P450 in the liver, displays a long half-life, and is taken orally.
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Ifosfamide
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Chemotherapy for the a treatment of Hodgkin lymphoma, as well as topically for T-cell lymohomas. acts by cross-linking DNA strands
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mechlorethamine
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Chemotherapy for the treatment of bladder cancer. may lead to ototoxicity.
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cisplatin
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Chemotherapy for the treatment of genitourinary tumores, lung cancer, and head/neck cancer. It is inorganic, and is activated by water to its hydrated intermediate which then covalently binds to neutrophilic sites on guanine.
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cisplatin
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Chemotherapy for the treatment of gastic and colorectal cancers. Main side effects of this DNA cross-linking drug include neurotoxicity and neutropenia.
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oxaliplatin
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chemotherapeutic agent used in the treatment of gastric and colorectal caners by cross-linking DNA. May lead to neurotoxicity and neutropenia.
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oxaliplatin
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chemotherapy administered via IV for the treatment of Hodgkin's lymphoma and malignant melanoma. This prodrug is ativated by hepatic cytochromes and creates DNA cross-links.
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dacarnazine
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Chemotherapy used in the treatment of malignant gliomas in combination with radiation therapy. It is taken orally and undergoes nonenzymatic activation at physiologic pH so it can cause DNA cross-linkages.
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temozolomide
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