Pharm 2 Antiseizure

Front 1

3 types of partial seizures

Back 1

simple and complex partial and 2nd generalized seizure

Front 2

describe simple partial and duration

Back 2

small focal- twitching thub, no LOC, and 20-60 seconds

Front 3

describe complex

Back 3

impaired LOC, 1st motionless and 2nd- automatism- purpuseless movements- 45 -90 sec

Front 4

describe grand mal

Back 4

tonic-clonic, urination, cry, and postictal state afterwords (CNS depression) 90

Front 5

describe absence

Back 5

petit mal- LOC staring, 10-30

Front 6

how long to qualify for status epilepticus and dangerous type

Back 6

30 min and generalized convulsive

Front 7

4 ways AEDs work

Back 7

supress Na and Ca, (reducing AP) GABA potentiation, andantag glutamate

Front 8

use pheytoin for what

Back 8

grand mal and partial(better stuff for these) but not absence

Front 9

use ethosuximide for

Back 9

absence but not grand mal or partial

Front 10

use valproic acid for

Back 10

all types of seizures

Front 11

how is determining dosage for absence different?

Back 11

use journaling and behaviour bc they happen so frequently like 100 times a day

Front 12

how to stop AEDs

Back 12

slowly 6 wks to several months

Front 13

therapeutic blood levels for phenytoin and other name

Back 13

dilantin, 10-20 narrow range

Front 14

adverse for pheyntoin

Back 14

nystagmus, diplopia, sedation (esp, ETOH), ataxia, gum swelling, preg-vit k, iv-hypo and dysrhythmia

Front 15

other name for tegerol

Back 15

carbamazepine

Front 16

tegerol useful for

Back 16

partial and grand mal not absense

Front 17

compare tegerol to pheyntoin

Back 17

tegerol has less side effects, less cognitive effects

Front 18

adverse for tegerol

Back 18

visual disturbances and ataxia but improves with time, leukopenia, anemia, and thrombocyto

Front 19

s x s of hematologic effects of tegerol and wbc for leukopenia and prevention

Back 19

3000, fever sore throat pallor infection petechiae bruising
blood counts before and after

Front 20

which antiseizure is addictive

Back 20

pheynlbarb

Front 21

how to minimize reaction to phenytoin IV

Back 21

go slowly

Front 22

another name for valproic acid

Back 22

depakote

Front 23

depakote used for

Back 23

all seizures, bipolar, migraines

Front 24

adverse effect of depakote

Back 24

pancreatitous and hepatotoxity

Front 25

which antiseizure is addictive

Back 25

pheynlbarb

Front 26

how to minimize reaction to phenytoin IV

Back 26

go slowly

Front 27

another name for valproic acid

Back 27

depakote

Front 28

depakote used for

Back 28

all seizures, bipolar, migraines

Front 29

adverse effect of depakote

Back 29

pancreatitous and hepatotoxity, increased ammonia, birth defects

Front 30

signs of a liver problem

Back 30

reduced appitette, N, lethargy, ab pain, jaundice

Front 31

drug used for absence seizures - 2 names

Back 31

ethosuximide and zarontin

Front 32

how does Phenobarb work?

Back 32

intensify GABA

Front 33

what class is phenobarn in?

Back 33

anticonvolsant barbituites

Front 34

pheno used for

Back 34

all seizures axcept absent

Front 35

pheno adverse

Back 35

Can cause nystagmus and ataxia in excessive doses.
sedation

Front 36

which drugs can decrease Vit K clotting factors?and with pregnant women?

Back 36

Phenobarbital, phenytoin, carbamazepine and primidone
Pregnant women should have K supplement, 10 mg/daily and baby 1mg at birth

Front 37

carbamazepine interactions

Back 37

warfarin and Oral Contra
phenytoin and phenobarb
grapefruits- increase levels

Front 38

what should women do with deprkote?

Back 38

increase folic acid 5mg daily

Front 39

only drug used for local muscle spasms

Back 39

dantrolene

Front 40

pheno adverse

Back 40

Can cause nystagmus and ataxia in excessive doses.
sedation

Front 41

which drugs can decrease Vit K clotting factors?and with pregnant women?

Back 41

Phenobarbital, phenytoin, carbamazepine and primidone
Pregnant women should have K supplement, 10 mg/daily and baby 1mg at birth

Front 42

carbamazepine interactions

Back 42

warfarin and Oral Contra
phenytoin and phenobarb
grapefruits- increase levels

Front 43

what should women do with deprkote?

Back 43

increase folic acid 5mg daily

Front 44

only drug used for local muscle spasms not in CNS

Back 44

dantrolene

Front 45

abrupt withdrawl from baclofen can cause

Back 45

hallucinations, seizure and paranoia

Front 46

adverse of dantrolene

Back 46

cns depression, hepatic toxic- women over 35, muscle weakness

Front 47

how does dantrolene work?

Back 47

suppresses release of Ca++

Front 48

uses of dantrolene?

Back 48

spasticity and malignant hyperthermia

Front 49

generic of baclofen

Back 49

lioresal