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24 Cards in this Set

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  • Back
Chlorpromazine (THORAZINE)
Typical
MOA: competitive block DA R's and H1, 5HT (seratonin)
older, less potent
avoid anti-cholinergics, hypotension, - ionotropic
Haloperidol (HALDOL)
Typical
MOA: competitive block DA R's and H1, 5HT (seratonin)
new, more potent
good for hyperactivity, agitation and mania
can cause hypothermia and anorexia
Clozapine (CLOZARIL)
Atypical
MOA: high affinity for D1, D4 and serotonin (5-HT) receptors (NOT D2)
intensification of dream activity REM sleep comprises up to 85% of total sleep time
agranulocytosis, only if unresponsive to at least 2 other drugs
Risperidone (RISPERDAL)
Atypical
MOA: 5-HT2, D2, alpha1 receptor antagonist
Improves both positive AND negative symptoms
Minimal sedation
Olanzapine (ZYPREXA)
Atypical
MOA: 5-HT>DA>Muscarinic>H1>alpha1
improves both positive AND negative symptoms
clearance about 40% higher in smokers and 30% lower in women
most severe side effects appear to be sedation and orthostatic hypotension
Lithium
packaged with carbonate or citrate as carrier salt
MOA: replace Na in nerve potentials, inhibits GCPR IP3 pathway (dec Ca)
dramatically improves mania, perhaps selectively modulates the neurons responsible for the manic state
Li+ toxicity includes severe CV and CNS derangements, can be fatal
Amitriptyline (Elavil)
anti-depress, tertiary
MOA: block reuptake of 5HT and NE
SE: sedation, cardiac arrhythmia, hypotension, seizure
Clomipramine (Anafranil)
anti-depress, tertiary
MOA: block reuptake of 5HT and NE
SE: sedation, cardiac arrhythmia, hypotension, seizure
Imipramine (Tofranil)
anti-depress, tertiary
MOA: block reuptake of 5HT and NE
SE: sedation, cardiac arrhythmia, hypotension, seizure
Desipramine (Nopramin)
anti-depress, secondary
MOA: block reuptake of 5HT>NE
SE: sedation, cardiac arrhythmia, hypotension, seizure
Nortriptyline (Pamelor)
anti-depress, secondary
MOA: block reuptake of 5HT>NE
SE: sedation, cardiac arrhythmia, hypotension, seizure
Fluoxetine (Prozac)
SSRI (selective serotonin reuptake inhibitor)
MOA: block reuptake of 5HT
SE: less cardio problems, impotency, impair glucose levels
Fluvoxamine (Luvox)
SSRI (selective serotonin reuptake inhibitor)
MOA: block reuptake of 5HT
SE: less cardio problems, impotency,
Paroxetine (Paxil)
SSRI (selective serotonin reuptake inhibitor)
MOA: block reuptake of 5HT
obsessive compulsive
SE: less cardio problems, impotency,
Sertraline (Zoloft)
SSRI (selective serotonin reuptake inhibitor)
MOA: block reuptake of 5HT
SE: less cardio problems, impotency
preferred in elderly
Citalopram (Celexa)
SSRI (selective serotonin reuptake inhibitor)
MOA: block reuptake of 5HT
SE: less cardio problems, impotency,
Escitalopram (Lexapro)
SSRI (selective serotonin reuptake inhibitor)
MOA: block reuptake of 5HT
SE: less cardio problems, impotency,
Phenelzine (Nardil)
MAOI (monamine oxidase inhibitor)
MOA: binds to enzyme that degrades NE, DA, and Seratonin
binds MAO-a and MAO-b
SE: hypertensive crisis (associated w/ amines in food or tyramine), hallucinations, convulsions
Tranylcypromine (parnate)
MAOI (monamine oxidase inhibitor)
MOA: binds to enzyme that degrades NE, DA, and Seratonin
binds MAO-a and MAO-b
SSE: hypertensive crisis (associated w/ amines in food or tyramine), hallucinations, convulsions
Selegiline
MAOI (monamine oxidase inhibitor)
MOA: binds to enzyme that degrades NE, DA, and Seratonin
binds MAO-b
SE: hypertensive crisis (associated w/ amines in food or tyramine), hallucinations, convulsions
Moclobemide
MAOI (monamine oxidase inhibitor)
MOA: binds to enzyme that degrades NE, DA, and Seratonin
binds MAO-a
SE: hypertensive crisis (associated w/ amines in food or tyramine), hallucinations, convulsions
Bupropion (Buspar)
2nd generation
used to quit smoking as adjunct
SE: seizures
Trazodone (Desyrel)
2nd generation
MAO: inhibits reuptake 5HT
SE: sedation, permanent impotency
Nefazodone
SE: sedation, impotency