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24 Cards in this Set
- Front
- Back
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Chlorpromazine (THORAZINE)
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Typical
MOA: competitive block DA R's and H1, 5HT (seratonin) older, less potent avoid anti-cholinergics, hypotension, - ionotropic |
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Haloperidol (HALDOL)
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Typical
MOA: competitive block DA R's and H1, 5HT (seratonin) new, more potent good for hyperactivity, agitation and mania can cause hypothermia and anorexia |
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Clozapine (CLOZARIL)
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Atypical
MOA: high affinity for D1, D4 and serotonin (5-HT) receptors (NOT D2) intensification of dream activity REM sleep comprises up to 85% of total sleep time agranulocytosis, only if unresponsive to at least 2 other drugs |
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Risperidone (RISPERDAL)
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Atypical
MOA: 5-HT2, D2, alpha1 receptor antagonist Improves both positive AND negative symptoms Minimal sedation |
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Olanzapine (ZYPREXA)
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Atypical
MOA: 5-HT>DA>Muscarinic>H1>alpha1 improves both positive AND negative symptoms clearance about 40% higher in smokers and 30% lower in women most severe side effects appear to be sedation and orthostatic hypotension |
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Lithium
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packaged with carbonate or citrate as carrier salt
MOA: replace Na in nerve potentials, inhibits GCPR IP3 pathway (dec Ca) dramatically improves mania, perhaps selectively modulates the neurons responsible for the manic state Li+ toxicity includes severe CV and CNS derangements, can be fatal |
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Amitriptyline (Elavil)
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anti-depress, tertiary
MOA: block reuptake of 5HT and NE SE: sedation, cardiac arrhythmia, hypotension, seizure |
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Clomipramine (Anafranil)
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anti-depress, tertiary
MOA: block reuptake of 5HT and NE SE: sedation, cardiac arrhythmia, hypotension, seizure |
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Imipramine (Tofranil)
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anti-depress, tertiary
MOA: block reuptake of 5HT and NE SE: sedation, cardiac arrhythmia, hypotension, seizure |
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Desipramine (Nopramin)
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anti-depress, secondary
MOA: block reuptake of 5HT>NE SE: sedation, cardiac arrhythmia, hypotension, seizure |
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Nortriptyline (Pamelor)
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anti-depress, secondary
MOA: block reuptake of 5HT>NE SE: sedation, cardiac arrhythmia, hypotension, seizure |
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Fluoxetine (Prozac)
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SSRI (selective serotonin reuptake inhibitor)
MOA: block reuptake of 5HT SE: less cardio problems, impotency, impair glucose levels |
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Fluvoxamine (Luvox)
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SSRI (selective serotonin reuptake inhibitor)
MOA: block reuptake of 5HT SE: less cardio problems, impotency, |
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Paroxetine (Paxil)
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SSRI (selective serotonin reuptake inhibitor)
MOA: block reuptake of 5HT obsessive compulsive SE: less cardio problems, impotency, |
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Sertraline (Zoloft)
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SSRI (selective serotonin reuptake inhibitor)
MOA: block reuptake of 5HT SE: less cardio problems, impotency preferred in elderly |
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Citalopram (Celexa)
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SSRI (selective serotonin reuptake inhibitor)
MOA: block reuptake of 5HT SE: less cardio problems, impotency, |
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Escitalopram (Lexapro)
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SSRI (selective serotonin reuptake inhibitor)
MOA: block reuptake of 5HT SE: less cardio problems, impotency, |
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Phenelzine (Nardil)
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MAOI (monamine oxidase inhibitor)
MOA: binds to enzyme that degrades NE, DA, and Seratonin binds MAO-a and MAO-b SE: hypertensive crisis (associated w/ amines in food or tyramine), hallucinations, convulsions |
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Tranylcypromine (parnate)
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MAOI (monamine oxidase inhibitor)
MOA: binds to enzyme that degrades NE, DA, and Seratonin binds MAO-a and MAO-b SSE: hypertensive crisis (associated w/ amines in food or tyramine), hallucinations, convulsions |
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Selegiline
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MAOI (monamine oxidase inhibitor)
MOA: binds to enzyme that degrades NE, DA, and Seratonin binds MAO-b SE: hypertensive crisis (associated w/ amines in food or tyramine), hallucinations, convulsions |
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Moclobemide
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MAOI (monamine oxidase inhibitor)
MOA: binds to enzyme that degrades NE, DA, and Seratonin binds MAO-a SE: hypertensive crisis (associated w/ amines in food or tyramine), hallucinations, convulsions |
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Bupropion (Buspar)
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2nd generation
used to quit smoking as adjunct SE: seizures |
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Trazodone (Desyrel)
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2nd generation
MAO: inhibits reuptake 5HT SE: sedation, permanent impotency |
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Nefazodone
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SE: sedation, impotency
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