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28 Cards in this Set
- Front
- Back
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Extrapyramidal dysfunction is more common with these agents, which block this subtype of dopamine receptor
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Older antipsychotic agents, D2 receptors
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MOA of neuroleptics
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Dopamine blockade
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Side effects occuring in antipsychotics that block dopamine
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Hyperprolactinemia, menorrhea, galactorrhea, confusion, mood changes, decreased sexual interest, and weight gain
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Antipsychotics that reduce positive symptoms only
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Older antipsychotics
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Newer atypical antipsychotics that also improve some of the negative symptoms and help acute agitation
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Olanzapine, aripiprazole, and sertindole
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Antipsychotic used in the treatment of psychiatric symptoms in patients with dementia
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Risperidone
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Atypical antipsychotic causing high prolactin levels
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Risperidone
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Newer atypical antipsychotic used for bipolar disorder, known to cause weight gain, and adversely affect diabetes
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Olanzapine
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Agent more frequently associated with extrapyramidal side effects that can be treated with benzodiazepine, diphenhydramine or muscarinic blocker
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Haloperidol
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Drug used in neuroleptic malignant syndrome
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Dantrolene
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Agents may exacerbate tardive dyskinesias (may be irreversible and there is no treatment)
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Muscarinic blockers
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Antipsychotic having the strongest autonomic effects
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Thioridazine
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Antipsychotic having the weakest autonomic effects
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Haloperidol
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Antipsychotic that does not block muscarinic or histamine receptors, and it prolongs the QT interval
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Sertindole
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Only phenothiazine not exerting antiemetic effects, can cause visual impairment due to retinal deposits, and high doses have been associated with ventricular arrhythmias
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Thioridazine
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Agent having no effect on D2 receptors, blocks D4, reserved for resistant schizophrenia, and can cause fatal agranulocytosis
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Clozapine
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Anti-psychotic not shown to cause tardive dyskinesia
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Clozapine
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Anti-psychotics available in depot preparation
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Fluphenazine and haloperidol
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Reduced seizure threshold
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Low-potency typical antipsychotics and clozapine
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Orthostatic hypotension and QT prolongation
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Low potency and risperidone
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Increased risk of developing cataracts
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Quetiapine
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Major route of elimination for Lithium
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Kidneys
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Patients being treated with lithium, who are dehydrated, or taking diuretics concurrently, could develop
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Lithium toxicity
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Drug increases the renal clearance hence decreases levels of lithium
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Theophylline
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Lithium is associated with this congenital defect
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Cardiac anomalies and is contraindicated in pregnancy or lactation
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DOC for bipolar affective disorder
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Lithium
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Concern using lithium
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Low therapeutic index
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SE of lithium
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Tremor, sedation, ataxia, aphasia, thyroid enlargement, and reversible diabetes insipidus
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