Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
17 Cards in this Set
- Front
- Back
- 3rd side (hint)
|
lovastatin
|
inhibit HMG CoA reductase, the rate limiting enzyme in cholesterol synthesis, v LDL and TG, ^ HDL
|
metabolized by P450 3A4
|
|
|
pravastatin
|
inhibit HMG CoA reductase, the rate limiting enzyme in cholesterol synthesis, v LDL and TG, ^ HDL
|
not metabolized by CPY450 pathway
|
|
|
simvastatin
|
inhibit HMG CoA reductase, the rate limiting enzyme in cholesterol synthesis, v LDL and TG, ^ HDL
|
metabolized by P450 3A4
|
|
|
fluvastatin
|
inhibit HMG CoA reductase, the rate limiting enzyme in cholesterol synthesis, v LDL and TG, ^ HDL
|
least potent
metabolized by P450 mediated pathway |
|
|
atorvastatin
|
inhibit HMG CoA reductase, the rate limiting enzyme in cholesterol synthesis, v LDL and TG, ^ HDL
|
more potent
metabolized by P450 3A4 |
|
|
rosuvastatin
|
inhibit HMG CoA reductase, the rate limiting enzyme in cholesterol synthesis, v LDL and TG, ^ HDL
|
more potent
not metabolized by CPY450 pathway |
|
|
cholestyramine
|
bile acid sequestrant
not absorbed systemically time released after meal can decrease absorption of fat soluble vitamins (vit K- bleeding) OK for young patients may raise TG levels |
|
|
|
colesevelam
|
bile acid sequestrant
not absorbed systemically time released after meal can decrease absorption of fat soluble vitamins (vit K- bleeding) OK for young patients may raise TG levels |
|
|
|
colestipol
|
bile acid sequestrant
not absorbed systemically time released after meal can decrease absorption of fat soluble vitamins (vit K- bleeding) OK for young patients may raise TG levels |
|
|
|
plant sterols
|
decrease cholesterol transport from micelles into enterocyte by inhibiting uptake through brush border protein NPC1L1, v LDL and TG, ^ HDL
|
naturally present in fruits and vegetables
structurally similar to cholesterol, but more hydrophobic displace cholesterol from micelles, increase excretion in stool |
|
|
ezetimibe
|
decrease cholesterol transport from micelles into enterocyte by inhibiting uptake through brush border protein NPC1L1, v LDL and TG, ^ HDL
|
statin used to counter increased cholesterol synthesis caused by reduction in absorption
ezetimibe levels increased with fibrates and cyclosporite |
|
|
gemfibrozil
|
fibrates- increase PPARa activity, changes lipid metabolism ^ HDL, v TG
|
|
|
|
fenofibrate
|
fibrates- increase PPARa activity, changes lipid metabolism ^ HDL, v TG
|
increases clearance of cyclosporine- must monitor transplant patients carefully
has fewer GI and myopathy adverse effects than gemfibrozil |
|
|
bezafibrate
|
fibrates- increase PPARa activity, changes lipid metabolism ^ HDL, v TG
|
|
|
|
ciprofibrate
|
fibrates- increase PPARa activity, changes lipid metabolism ^ HDL, v TG
|
|
|
|
Omecor
|
Omega 3 fatty acids
|
|
|
|
Niacin
|
reduces free FA release from adipose tissue, increases plasma residence time for apoAiI
|
v LDL and TG, ^ HDL, flushing occurs because of prostaglandin G coupled reaction, hyperuricemia- gout, associated with impaired insulin sensitivity
|
