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14 Cards in this Set
- Front
- Back
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Drugs that induce histamine release
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d-tubocurarine, succinylcholine, morphine, vancomycin
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H1 receptor coupling mechanism
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coupled to phospholipase C --> IP3 formation --> Ca release from ER
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H2 receptor coupling mechanism
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stimulation and adenyl cyclases and cAMP dependent kinase activation
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H1 mechanism of action
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Inverse agonist, binds irreversibly to inactive form of receptor
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Chlorpheniramine: Chlortrimeton
1) Drug class 2) CNS effect |
1) 1st generation H1 antihistamine
2) Moderate sedation, slight antimotion sickness |
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Cetirizine: Zyrtec
1) Drug class 2) Excretion |
1) 2nd generation H1 antihistamine
2) Renal secretion --> patients with renal impairment must be given lower dose |
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Diphenhydramine: Benadryl
CNS effects |
1st generation H1 antihistamine
Marked sedation, moderation antimotion sickness effects |
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Deminhydrinate: Dramamine
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1st generation H1 antihistamine
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Cyclizine: Marezine
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1st generation H1 antihistamine
Moderate sedation, marked antimotion sickness effects |
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Meclizine: Antivert
CNS effects |
1st generation H1 antihistamine
moderate sedation effects, marked antimotion sickness effects |
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Promethazine: Phenergan
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1st generation H1 antihistamine
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Loratidine: Clariton
Drug type and metabolism |
2nd generation H1 antihistamine, p450 metabolized
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Desloratidine: Clarinex
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Made from loratidine via p450 metabolism. Metabolism unclear
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Fexofenadine: Allegra
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2nd generation H1 antihistamine, excreted unchanged in kidney, daughter drug of terfenadine
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