Pharm 17: Skeletal Muscle Relaxants

Front 1

Structurally related to acetylcholine, used to produce muscle paralysis in order to facilitate surgery or artifical ventilation. Full doses lead to respiratory paralysis and require ventilation

Back 1

Neuromuscular blocking drugs

Front 2

These drugs strongly potentiate and prolong effect of neuromuscular blockade (NMB)

Back 2

Inhaled anesthetics, especially isoflurane, aminoglycosides, and antiarrhythmic

Front 3

These prevent the action of Ach at the skeletal muscle endplate to produce a "surmountable blockade," effect is reversed by cholinesterase inhibitors (ex. neostigmine or pyridostigmine)

Back 3

Nondepolarizing type antagonists

Front 4

Agent with long duration of action and is sost likely to cause histamine release

Back 4

Tubocurarine

Front 5

Non-depolarizing antagonist has short duration

Back 5

Mivacurium

Front 6

Agent can blocking muscarinic receptors

Back 6

Pancuronium

Front 7

Agent undergoing Hofmann elimination (breaking down spontaneously)

Back 7

Atracurium

Front 8

One depolarizing blocker that causes continuous depolarization and results in muscle relaxation and paralysis, causes muscle pain postoperatively and myoglobinuria may occur

Back 8

Succinylcholine

Front 9

During Phase I these agents worsen the paralysis by succinylcholine, but during phase II they reverse the blockade produced by succinylcholine

Back 9

Cholinesterase inhibitors

Front 10

Agents acting in the CNS or in the skeletal muscle, used to reduce abnormally elevated tone caused by neurologic or muscle end plate disease

Back 10

Spasmolytic drugs

Front 11

Facilitates GABA presynaptic inhibition

Back 11

Diazepam

Front 12

GABA agonist in the spinal cord

Back 12

Baclofen

Front 13

Similar to clonidine and may cause hypotension

Back 13

Tizanidine

Front 14

DOC for malignant hyperthermia by acting on the sacroplasmic reticulum or skeletal muscle

Back 14

Dantrolene

Front 15

Agent used for acute muscle spasm

Back 15

Cyclobenzaprine