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13 Cards in this Set
- Front
- Back
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Two big events resulting in more papers in polymorphisms
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Advent of PCR and the 1st draft of the human genome.
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BiDil
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Drug uesd for heart failure in African American pts.
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Synonymous polymorphism
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Does not change coding amino acids
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Nonsynonymous polymorphisms
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Changes coding amino acids.
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Pharmacogenetics
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how a genetic variant affects a drug (its binding, activation, abs, distrib, metab and elim)
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Pharmacogenomics
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How a drug affects genomics (gene/protein expression)
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Pharmacogenetics can affect...(2)
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drug metabolism (p450s usually) or the drug target itself
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Danger in lacking an enzyme with chemo agents
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Can result in the accumulation of inactive metabolites leading to toxicity.
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R212C gene
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People with this gene have increased risk of adverse CV events.
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Principles of genetic detection. Should be...
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easy/quick
Low cost reliable large scale. |
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Pharmacoeconomic issues in genetic profiling
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Narrow of drug market
Orphan drug syndrome Orphan population syndrome. |
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Largest family of receptors?
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G-proteins
(this is the R212C one that has implications with CV) Can also affect asthma. |
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Smiley face - graphs
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Polymorphisms of a receptor don't affect toxicity, because that is mediated at other spots.
So by pumping up the drug concentration, all people get the same increase in toxicity but there is an in terms of ther. effects for the people who have normal wt receptors. |
