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32 Cards in this Set

  • Front
  • Back
What is pharmacoDYNAMICS?
What the chemical does to the body, mechanism of action
What is pharmacoKINETICS?
What the body does to the chemical, time course and dynamics of the drug, absorption, distribution
Cimetidine causes
Reduced gastric secretion
What does aspirin do?
Covalently alkylates cyclooxygenase
Weak binders are usually more selective
NOTES
What does DAG (diacylglycerol) do?
Activates Protein Kinase C (PKC)
Nicotinic aceylcholine receptor is what type of channel?
Na+ channel
GABA receptor is what type of channel?
Cl- channel
cAMP is a 2nd messenger that activates
PKA and ion channel
cGMP activates
protein kinase G (PKG)
Guanylyl cyclase is acivated by
NO
Equation for Vd
Amount of drug in body/Plasma drug concentration
Equation for Clearance
Rate of elimination/plasma drug concentration
Half life equation
(0.693 x Vd)/CL
Maintenance Dosage Equation
Dosing Rate = (CL x Desired plasma concentration)/ Bioavailability
Loading Dose equation
Loading dose = (Vd x desired plasma concentration) / Bioavailability
Examples of receptors that are protein kinases
EGF (epidermal growth factor) receptor
Cytokine receptor
Examples of ion channel receptors
1) Nicotinic receptor
2) GABA
3) Glu
4) Asp
5) Gly
What does phosphodiesterase do?
Cleaves cAMP
cAMP activates
Protein kinase A and ion channels
cGMP activates
Protein Kinase G
Chronic application of agonists on receptors causes
Desensitization and tachyphylaxis
Chronic application of antagonists on receptors causes
Supersensitivity and rebound effect
Lower ED50 means
Higher POTENCY
Remember ED50 means apparent AFFINITY of drug to receptor
Notes
Potency means
How much of the drug you need to occupy half of the receptors
Partial agonists compete with full agonists
Notes
Same slopes indicates same mechanisms
Notes
half life equation 2
.693/rate of elimination (slope) on a log scale
Albumin is the major binding protein for acidic, basic, or neutral drugs?
Neutral AND acidic drugs
Basic drugs bind what in plasma
alpha-1-acid glycoprotein
Ke =
CL/Vd