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24 Cards in this Set
- Front
- Back
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MOA of sildenafil (Viagra)
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Inhibits phosphodiesterase-5, enhancing effects of nitric oxide-activated increases in cGMP
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Drugs used in the management of angina
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Aspirin, Nitrates, CCB, and Beta blockers
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Aspirin reduces mortality in unstable angina by
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Platelet aggregation inhibition
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MOA of nitrates
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Relax vascular smooth muscle, at low doses dilate veins and at high doses dilate arterioles
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Nitrate used for acute anginal attacks
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Nitroglycerin sublingual tablets
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Nitrate used to prevent further attacks
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Oral and transdermal forms of nitroglycerin
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Nitrate free intervals are needed due to
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Tolerance
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SE of nitrates
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Postural hypotension, reflex tachycardia, hot flashes, and throbbing headache due to meningeal artery dilation
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CCB are DOC for
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Prinzmetal's angina
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Beta blockers are used for which type of angina attack
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Classic
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MOA of Cardiac glycosides (eg. digoxin)
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Indirectly increase intracellular calcium and cardiac contractility by inhibiting Na+/K+ ATPase
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Digoxin is used in
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Atrial fibrillation and CHF
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Digoxin toxicity can be precipitated by
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Hypokalemia
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Antidote for digoxin toxicity
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Digibind
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Phosphodiesterase inhibitors that increase mortality and have been found to have NO beneficial effects
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Amrinone and milrinone
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SE of amrinone
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Thrombocytopenia
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Beta 1 agonists used in acute CHF
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Dobutamine and dopamine
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Diuretics work in CHF by
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Reducing preload
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Beta blockers work in CHF by
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Reducing progression of heart failure (never use in acute heart failure)
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Peptide drug used to treat CHF
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Nesiritide (BNP)
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MOA of nesiritide
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Increasing sodium excretion and decreases arterial and venous tone
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SE of nesiritide
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Excessive hypotension and kidney failure
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Agent used in CHF that is a selective alpha and nonselective beta blocker
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Carvedilol
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Agent used in acutely decompensated CHF resembling natriuretic peptide
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Nesiritide (Natrecor)
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