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9 Cards in this Set
- Front
- Back
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Structure of cardiac glycosides
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Steroid basically.
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Pharmacodynamics of digoxin
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Inotropic - inhib of Na/K ATPase to increase Ca++ intracellularly and make actin/myosin interaction more intense.
Increases vagal tone so there is slower conduction. So digoxin is useful to achieving rate control in AFib (not rhythm control) and treating CHF. |
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SEs of digoxin
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Afterpotentials - so it is proarrythmic
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Another drug good for CHF and AFib
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Beta blocker.
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Other SEs of digoxin
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GI (anorexia, n/v, abd pain, diarrhead) and CNS (disorientation, nightmares, green-yellow vision)
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Furosemide with digoxin
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Often used together for CHF effects.
But furosemide causes hypokalemia so the pro-arrythmic potential of digoxin becomes even worse. |
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Other drug int with digoxin
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Abs red by antacids, quinidine reduces its renal clearance, amiodarone.
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Contraind for digoxin
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Vent tachy, VFib, WPW, AV or SA block, IHSS
These are relative - just be careful with these - Hypoxia and hypokalemia. |
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Half life of digoxin
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Very long.
It is not often given because the toxic effects could last for weeks. |
