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11 Cards in this Set
- Front
- Back
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Ach
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M & N Activity
AChE Hydolysis Short half life- no clinical use |
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Bethanachol
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M agonist
Rx: Ileus (postop/neurogenic), urinary retention (--> stimulates voiding) |
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Methacholine
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Muscarinic >> Nicotinic
Diagnose Bronchial hyperreactivity in asthma |
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Pilocarbine
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Muscarinic Agonist
R: Glaucoma (topical), Xerostomia |
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Edrophonium
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AchE Inhibitor
Short acting Dx: myasthenia gravis (differentiate myasthenia from cholinergic crisis |
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Physostigmine
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AchE Inhibitor (Indirect Cholinergic agonist) - REVERSIBLE
Tertiary Amine (enters CNS) Rx: Glaucoma; antidote in atropine overdose |
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Neostigmine, Pyridostigmine
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AchE Inhibitor (Indirect cholinergic agonist) - REVERSIBLE
Quaternary amine (NO CNS entry) Rx: ileus, urinary retention, myasthenia tx, reversal of nondepolarizing muscle blockade |
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Donepezil, Tacrine
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AchE Inhibitor (indirect cholinergic agonist) - REVERSIBLE
Lipid soluble (CNS Entry) Rx: Alzheimer's disease |
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Organophosphate
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IRREVERSIBLE AchE Inhibitor (indirect cholinergic agonist)
- lipid soluble -irreversible inhibitors Rx: Glaucoma (Ecothiophate) Insectisides: malathion, parathion Nerve Gas: Sarin Toxicity: excessive muscarinic & nicotinic stimulation: Diarrhea, Urinary, Miosis, Bradycardia, Cronchoconstriction, Muscle & CNS excitation, Lacrimation, Salivation, Sweating |
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Pralidoxime
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reverses cholinergic toxicity of AchE Inhibitors (Edrophonium, Neostigmine, Pyridostigmine, Physostigmine, Donezepil, Tacrine). NOT orgaophosphates (ecothionphate, sarin, parathion or malathion)
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Atropine
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Muscarinic Receptor Antagonist
Tertiary amine, enters CNS |
