Pharm 1

Front 1

Cocaine

Sympathomimetics: Local Anesthetic, Drug of Abuse

Back 1

-Monoamine uptake blocker

-Cocaine blocks DAT (and NET and SERT).

This blockade potentiates and prolongs

the actions of the monoamines

Front 2

Methylphenidate (Ritalin)

Sympathomimetics: Drug for ADHD, Narcolepsy

Back 2

(MPH) increases DA and NE levels (blocks DAT and NET). MPH is structurally similar to amphetamine, but its effects are

similar to those of cocaine (they have similar affinity for DAT and act on the same brain sites).

Front 3

Amphetamine

Sympathomimetics: drug of ADHD, narcolepsy and drug of abuse

Back 3

-Vesicular monoamine transporter blocker

-Releases monoamines at synapses

-Inhibits uptake of monoamine

o Amph serves as a substrate for DAT, therefore competitively inhibiting DA reuptake (extracellular DA increases);

o Once inside the terminal, Amph disrupts the vesicular storage of monoamines, causing increase in cytoplasmic DA levels.

Monoamines are pumped out of the terminal (non-vesicularly) by a reverse action of DAT (extracellular DA increases).

Front 4

Methamphetamine

Sympathomimetics: Drug of Abuse

Back 4

Vesicular monoamine transporter blocker

-Amphetamine derivative (N- methylated); similar pharmacological effects to cocaine and amphetamine but longer duration.

-Methamphetamine is directly toxic to midbrain dopamine neurons. Chronic leads to

severe structural and functional changes in areas of the brain associated with emotion

and memory

Front 5

MDMA

Sympathomimetics: Drug of abuse

Back 5

Vesicular monoamine transporter blocker

Front 6

Caffine

Methylxanthines

Back 6

A. Translocation of extracellular calcium;

B. Increase in cAMP and cGMP caused by inhibition of phosphodiesterase;

C. Blockade of Adenosine Receptors, mainly A2a. (main)

Front 7

Nicotine

Back 7

Readily crosses the bbb. At low doses

it’s a stimulant.

• Peripheral effects: Causes an autonomic arousal, increases blood pressure

and heart rate, stimulates motility of GI tract and bladder.

-Nicotine acts on nAChRs in the VTA to

provoke dopamine release in the Nacc;

-Nicotine stimulates release of glutamate,

which act on Glu receptors on VTA

dopamine neurons, stimulating dopamine

release into the nucleus accumbens .