Pharm 1

Front 1

bactericidal

Back 1

cause death of cells

Front 2

bacteriostatic

Back 2

interfere with cells ability to reproduce

Front 3

natural resistance

Back 3

do not use the process affected by a particular drug

Front 4

acquired resistance

Back 4

exposures to anti-infectives stimulates adapation

Front 5

prophylaxis

Back 5

use of anti-infectives to prevent infection

Front 6

gram negative bacteria

Back 6

cell wall retains stain. most common cause of respiratory infection

Front 7

gram positive

Back 7

cell wall does not retain stain. common cause of gi/gu infections.

Front 8

aminoglycosides (what for)

Back 8

to treat gram negative aerobic bacilli

Front 9

aminoglycosides (drugs)

Back 9

amikacin. gentamicin*. kanamycin. neomycin. streptomycin. tobramycin*.

Hint 9

-cin

Front 10

aminoglycosides (moa)

Back 10

bactericidal. inhibits protein synthesis

Front 11

aminoglycosides (adverse effects)

Back 11

ototoxity. nephrotoxicity. neurotoxicity. bone marrow suppression.

Front 12

carbapenems ( what for)

Back 12

broad spectrum. effective on both gram positive and negative.

Front 13

carbapenems

Back 13

doripenem. ertapenem. imipenem-cilastatin (synergistic). meropenem*.

Hint 13

-em

Front 14

Carbapenems (Moa)

Back 14

bactericidal. inhibits cell wall synthesis.

Front 15

carbapenems (adverse effects)

Back 15

toxic in Gi. superinfections. pseudomembranous colitis, c. difficile. cns effects.

Front 16

cephalosporins (1st Gen drugs)

Back 16

cefadroxil. cefazolin. cephalexin.

Hint 16

xilinxin

Front 17

cephalosporins 1st Gen what for

Back 17

gram positive and some negative(PEcK)

Front 18

cephalosporins 2nd Gen for what

Back 18

all of 1st gen and HEN

Front 19

cephalosporins 3rd Gen for what

Back 19

weak against gram positive, more potent against negative. PECK and HEN plus serratia marcescens

Front 20

cephalosporins 4th gen for what

Back 20

in development. active against positive, negative and cephalosporins- resistant staph and p aeruginosa

Front 21

cephalosporins (moa)

Back 21

bactericidal and bacteriostatic. interfere with cell wall building, prevent biosynthesis of framework of the cell wall.

Front 22

fluoroquinolones ( what for)

Back 22

synthetic class of antibiotics with broad spectrum activity.

Front 23

fluoroquinolones (drugs)

Back 23

ciprofloxacin*. gemifloxacin. levofloxacin*. moxifloxacin. norfloxacin. ofloxacin.

Hint 23

-floxacin

Front 24

fluoroquinolones (moa)

Back 24

enter cell passively and interferes with DNA enzymes.

Front 25

penicillins

Back 25

-cillin

Front 26

penicillinase-resistance drugs

Back 26

nafcillin. oxacillin

Front 27

sulfonamides (drugs)

Back 27

sulfadiazine. sulfadalazine. cotrimoxazole

Hint 27

inhibits folic acid synthesis

Front 28

Tetracycline (drugs)

Back 28

demeclocycline. doxycycline. minocycline. tetracycline.

Hint 28

four rings- tetra. -cycline

Front 29

antimycobacterials (leprostatic drug)

Back 29

dapsone

Front 30

antimycobacterials (anti tb 1st line)

Back 30

ethambutol. isoniazid. pyrazinamide. rifampin. rifapentine. streptomycin.

Front 31

antimycobacterials (anti tb 2nd line)

Back 31

capreomycin. cycloserine. ethnamide. rifabutin.

Front 32

antimycobacterials (moa ae)

Back 32

-acts in DNA or rna leading to no growth. anti tb drugs to decrease resistance.
-neuritis. dizziness. headache. malaise. drowsiness. halucination. nvd. anorexia. abd pain. body turns orange.

Front 33

lincosamides drugs

Back 33

clindamycin lincomycin

Front 34

macrolides

Back 34

azithromycin. clarothomycin. erythromycin.

Front 35

macrolides/lincosamides (MOA, adverse)

Back 35

-bactericidal or bactereostatic. Change protein structure.
-pseudomembranous colitis. cns:confusion abnormal thinking. uncontrollable emotion.

Front 36

agents for influenza a and respiratory viruses

Back 36

amantadide. oseltamivir. ribavirin. rimantadine. zanamir.

Front 37

agents for influenza a and respiratory virus. (moa, adverse)

Back 37

-not known, believe to prevent shedding of viral protein coat and entry of the virus into the cells.
-lightheadeness,diziness, insomia, nausea, orthostatic hypotension, urinary retention

Front 38

agents for herpes and cytomegalovirus

Back 38

acyclovir. cidofovir. famciclovir. foscarnet. ganciclovor. valacyclovir. valaganciclovir

Hint 38

-ovir

Front 39

agents of herpes and cytomegalovirus (moa. adverse)

Back 39

-inhibit viral DNA replication by competing with viral substrates to form shorter non effective DNA chains.
-n/v,headache, depression, parathesias, neuropathy, rash hair loss. renal damage. granulocytopenia. seizure.

Front 40

nonnucleoside reverse transcripase inhibitors (moa, adverse)

Back 40

-bind directly to hiv reverse transcriptase, blocking polymerase activity.
-dry mouth. constipation or diarrhea. nausea. abdominal pain. dyspepsia. diziness. Blurry vision. headache. flu like symptoms.

Front 41

nucleoside reverse transcriptase inhibitors (moa, ae)

Back 41

-complete with natural nucleoside within the cel that the virus used to build DNA, but lack of substance needed to extend the chain so the virus DNA cannot insert into the host dna.
-fatal hypersensitivity. pancreatitis. hepatomegaly. bone marrow suppression.

Front 42

protease inhibitors (moa ae)

Back 42

-an hiv particle is immature and noninfective. these drugs block protease.
-nvd. anorexia. elevated lipids. partial rash. pruritis.

Hint 42

-avir

Front 43

anti hepatitis b agents. drugs

Back 43

telvivudine. adefovir. entecavir.

Hint 43

TAE

Front 44

anti hepatitis b agents (moa ae)

Back 44

-inhibits reverse transcriptase and cause of DNA chain termination which block replication.
-headache. diziness. nausea. diarrhea. elevated liver enzymes. lactic acidosis and renal impairment.

Front 45

azole antifungals (drugs)

Back 45

-azole

Front 46

azole (moa. ae)

Back 46

-fungacidal: binds with stroll to cause death. fungastatic: interfere with cell replication.
-liver toxicity. severe effects on fetus/nursing babies.

Front 47

other antifungal drugs

Back 47

amphotecin B. flucytosine. griseofulvin. nystatin.

Front 48

other antifungal (moa. ae)

Back 48

-bukas took sterols in cell wall changing permeability. prevent reproduction.
-amphotericin b: renal impairment. bone marrow suppression. diarrhea. aborexia. phlebitis. griseofulvin:mild headache. cns.

Front 49

cephalosporins 2nd Gen drugs

Back 49

cephaclor. cefoxitin. cefprozil. cefuroxime.

Front 50

cephalosporins 3rd gen drugs

Back 50

cefdinir. cefotaxime. cefpodoxime. ceftazidime. ceftibuten. ceftizoxime. ceftriaxone.

Front 51

cephalosporins 4th gen

Back 51

cefditoren. cefepime. ceftaroline.

Front 52

cephalosporins ae

Back 52

nvd. anorexia. abdominal pain. pseudomembranous colitis. headache diziness lethargic. neurotoxicity.

Front 53

fluoroquinolones ae

Back 53

-generally mild. headache diziness insomia depression. nvd. photosensitivity.

Front 54

penicillin moa ae

Back 54

-bactericidal. interfere with cells ability to build walls during division. selective toxicity.
-nvd. abd pain. superinfection. pain and inflammation at injection site.

Front 55

sulfonamides moa ae

Back 55

-inhibit folic acid synthesis, which interferes dna and rna precursors.
-nvd. abd pain. anorexia. stomatitis. hematuria. crystaluria. proteinuria. headache diziness vertigo depression. bone marrow supression. photosensitivity.

Front 56

tetracycline moa ae

Back 56

-inhibits protein synthesis, can be toxic to humans in high level.
-nvd. abd pain. glositis. dysphagia. damage in teeth and bones. superinfections. intercranial hypertension.
-do not take drug with food or dairy.